Yang Chia-Wei, Liu Kunli, Yao Cheng-You, Li Bo, Juhong Aniwat, Qiu Zhen, Huang Xuefei
Department of Chemistry and Institute for Quantitative Health Science and Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
Institute for Quantitative Health Science and Engineering and Department of Electrical and Computer Engineering, Michigan State University, East Lansing, Michigan 48824, United States.
ACS Appl Nano Mater. 2022 Dec 23;5(12):18912-18920. doi: 10.1021/acsanm.2c04687. Epub 2022 Dec 5.
Breast cancer is the leading cause of cancer-associated deaths among women. Techniques for non-invasive breast cancer detection and imaging are urgently needed. Multimodality breast cancer imaging is attractive since it can integrate advantages from several modalities, enabling more accurate cancer detection. In order to accomplish this, indocyanine green (ICG)-conjugated superparamagnetic iron oxide nanoworm (NW-ICG) has been synthesized as a contrast agent. When evaluated in a spontaneous mouse breast cancer model, NW-ICG gave a large tumor to normal tissue contrasts in multiple imaging modalities including magnetic particle imaging, near-infrared fluorescence imaging, and photoacoustic imaging, providing more comprehensive detection and imaging of breast cancer. Thus, NW-ICGs are an attractive platform for non-invasive breast cancer diagnosis.
乳腺癌是女性癌症相关死亡的主要原因。迫切需要用于非侵入性乳腺癌检测和成像的技术。多模态乳腺癌成像具有吸引力，因为它可以整合多种模态的优势，从而实现更准确的癌症检测。为了实现这一点，已合成了吲哚菁绿（ICG）共轭超顺磁性氧化铁纳米蠕虫（NW-ICG）作为造影剂。在自发小鼠乳腺癌模型中进行评估时，NW-ICG在包括磁粒子成像、近红外荧光成像和光声成像在内的多种成像模态中，实现了大的肿瘤与正常组织对比度，为乳腺癌提供了更全面的检测和成像。因此，NW-ICG是用于非侵入性乳腺癌诊断的一个有吸引力的平台。
