Nashi Nazrul, Kagda Fareed Hy
University Orthopaedic, Hand and Reconstructive Microsurgery Cluster, National University Health System, Singapore, 1E Kent Ridge Road, 119228, Singapore.
Department of Orthopaedic Surgery, Ng Teng Fong General Hospital, National University Health System, Singapore, 1 Jurong East Street 21, 609606, Singapore.
J Clin Orthop Trauma. 2023 Aug 5;43:102231. doi: 10.1016/j.jcot.2023.102231. eCollection 2023 Aug.
Bone graft in trauma surgery is commonly used in managing bone defects, non-union, fracture related infections, arthrodesis or to provide structural support in fractures. A variety of bone grafts are made available to the treating physician, which includes autograft, allograft and bone graft substitutes. The future of bone grafting in trauma surgery is exciting with the incorporation of technological advancement such as gene therapy, 3D-printing and tissue engineering. Regardless, there are still limitations to what we understand regarding current bone grafting techniques with conflicting literature on their clinical utility and indication. The aim of this review article therefore is to take a step back and critically evaluate the current concepts of bone grafting in trauma surgery, with special emphasis made on reviewing the types of bone graft, biology of bone graft incorporation and indication for its use in various clinical scenarios.
骨移植在创伤外科手术中常用于处理骨缺损、骨不连、骨折相关感染、关节融合或为骨折提供结构支撑。治疗医生可使用多种骨移植材料，包括自体骨移植、异体骨移植和骨移植替代物。随着基因治疗、3D打印和组织工程等技术进步的融入，创伤外科手术中骨移植的未来令人期待。尽管如此，我们对当前骨移植技术的理解仍存在局限性，关于其临床效用和适应症的文献相互矛盾。因此，这篇综述文章的目的是退一步，批判性地评估创伤外科手术中骨移植的当前概念，特别强调回顾骨移植的类型、骨移植融合的生物学机制及其在各种临床场景中的使用适应症。
