Paramasivam Praveen Kumar, Sahu Pankaj Kumar, Bishnoi Tapasya, Dutta Angshuman, Yadav Mukesh Kumar, Marlapudi Sudheer Kumar
Department of ENT, Command Hospital Airforce Bangalore, Cambridge Layout, AGARAM Post, Bangalore, Karnataka 560007 India.
Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):2042-2048. doi: 10.1007/s12070-023-03805-2. Epub 2023 Apr 25.
Laryngopharyngeal reflux disease (LPRD) is the result of retrograde flow of gastric contents to the laryngopharynx which comes in contact with tissues of the upper aerodigestive tract. Due to ill defined criteria for diagnosis & followup, LPRD patients are underdiagnosed & undertreated. Reflux Symptom Index (RSI) and the Reflux Finding Score (RFS) are two clinical methods which can be utilised especially in the outpatient setup. This study was done with the aim to assess various laryngoscopic findings in patients with LPRD diagnosed symptomatically and examine the correlation between the RSI & RFS by comparing these two indices. This prospective analytical study was conducted at a tertiary care centre in Bangalore in the Department of ENT for a period of 24 months between Dec 2020 to Dec 2022. The study included patients aged 18 to 60 years diagnosed with LPRD based on symptoms as per RSI score (> 13). RSI & RFS were assessed on diagnosis and patients were followed up for 1, 3 & 6 months for assessment. Total 96 patients were enrolled, with mean age of be 42.49 ± 11.33 years. Prevalence was found to be more in females (61.5%). The most common symptom according to RSI was frequent throat clearing & globus sensation (sensation of something sticking in throat) and most common finding according to RFS was erythema/hyperemia. The mean score of RSI and RFI was found to reduce with treatment at different intervals in follow-up visits. There was a significant strength of association between the RSI and RFS at baseline, 1st month, 3rd month and 6th month of follow-up (r = 0.568, r = 0.684, r = 0.774, r = 0.736 respectively) ( < 0.001).The RFS and RSI showed statistically significant strong relationships between total scores and sign and symptom characteristics. On follow-up, there was a significant reduction in the RSI which was also correlated with a reduction in RFS.
喉咽反流病（LPRD）是胃内容物逆向流动至喉咽并与上呼吸道消化道组织接触的结果。由于诊断和随访标准不明确，LPRD患者存在诊断不足和治疗不足的情况。反流症状指数（RSI）和反流发现评分（RFS）是两种临床方法，尤其可用于门诊环境。本研究旨在评估有症状诊断的LPRD患者的各种喉镜检查结果，并通过比较这两个指标来检查RSI与RFS之间的相关性。这项前瞻性分析研究于2020年12月至2022年12月期间在班加罗尔的一家三级医疗中心的耳鼻喉科进行，为期24个月。该研究纳入了年龄在18至60岁之间、根据RSI评分（>13）基于症状诊断为LPRD的患者。在诊断时评估RSI和RFS，并对患者进行1、3和6个月的随访以进行评估。共纳入96例患者，平均年龄为42.49±11.33岁。发现女性患病率更高（61.5%）。根据RSI，最常见的症状是频繁清嗓和咽异感症（感觉有东西卡在喉咙里），根据RFS，最常见的发现是红斑/充血。在随访的不同时间间隔，发现RSI和RFI的平均评分随着治疗而降低。在随访的基线、第1个月、第3个月和第6个月，RSI和RFS之间存在显著的关联强度（r分别为0.568、0.684、0.774、0.736）（<0.001）。RFS和RSI在总分与体征和症状特征之间显示出统计学上显著的强关系。在随访中，RSI有显著降低，这也与RFS的降低相关。
