Lim Alison Emily, Hurley Rhona, Slim Mohd Afiq Mohd, Melia Louise
Department of Ear, Nose and Throat, Queen Elizabeth University Hospital, 1345 Govan Rd, Glasgow, G51 4TF UK.
Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):2707-2712. doi: 10.1007/s12070-023-03581-z. Epub 2023 May 3.
The detection of androgen receptors within Juvenile Nasopharyngeal Angiofibroma (JNA) has prompted investigation of the role of Flutamide. The aim of this review is to evaluate Flutamide as a possible neo-adjuvant treatment for JNA. Literature searches were conducted using MEDLINE, EMBASE and Web of Science. The Joanna Briggs Institute (JBI) checklist was used to assess risk of bias. The Oxford Centre of Evidence-Based Medicine (OCEBM) Levels of Evidence was used to stratify the evidence level. Literature searches were conducted using MEDLINE, EMBASE and Web of Science. Flutamide as neo-adjuvant treatment potentially causes a reduction in JNA tumor volume by ≥ 25%. Based on the current limited evidence, Flutamide has a limited role in JNA management and further research is required. Its utilization should only follow discussion with the patient, their families, and within the multidisciplinary team.
在青少年鼻咽血管纤维瘤（JNA）中检测到雄激素受体，这促使人们对氟他胺的作用展开研究。本综述的目的是评估氟他胺作为JNA一种可能的新辅助治疗方法的效果。使用MEDLINE、EMBASE和科学网进行文献检索。采用乔安娜·布里格斯研究所（JBI）核对清单评估偏倚风险。运用牛津循证医学中心（OCEBM）证据水平对证据等级进行分层。使用MEDLINE、EMBASE和科学网进行文献检索。氟他胺作为新辅助治疗可能使JNA肿瘤体积减少≥25%。基于目前有限的证据，氟他胺在JNA治疗中的作用有限，需要进一步研究。其使用应仅在与患者及其家属讨论后，并在多学科团队内部进行。
