青少年鼻咽血管纤维瘤的辅助治疗：我们应如何应对复发？
Adjunctive Treatment in Juvenile Nasopharyngeal Angiofibroma: How Should We Approach Recurrence?
作者信息
Scholfield Daniel W, Brundler Marie-Anne, McDermott Ann-Louise, Mussai Francis, Kearns Pamela
机构信息
*ENT Department, Whipps Cross Hospital, London †Department of Pathology ‡ENT Department, Birmingham Children's Hospital §School of Cancer Sciences, University of Birmingham ∥Paediatric Oncology Department, Birmingham Children's Hospital, Birmingham, UK.
出版信息
J Pediatr Hematol Oncol. 2016 Apr;38(3):235-9. doi: 10.1097/MPH.0000000000000524.
A recent case of advanced, recurrent juvenile nasopharyngeal angiofibroma (JNA) at our institution has highlighted the limited evidence regarding adjunctive treatment. We present the case of a 10-year-old boy who is the first to undergo multiple-staged surgical resections alongside vincristine treatment. We performed a review of the literature analyzing the roles of radiation therapy, cytotoxic drugs, and novel targeted agents in JNA relapse. Small cohort studies suggest radiotherapy and flutamide are the most rational treatment options for residual and recurrent JNA. Our review highlights the need for further research into the management of primary and recurrent JNA.
我院近期收治的一例晚期复发性青少年鼻咽血管纤维瘤（JNA）病例凸显了辅助治疗方面证据有限的问题。我们报告了一例10岁男孩的病例，他是首例在接受长春新碱治疗的同时进行多阶段手术切除的患者。我们对文献进行了综述，分析了放射治疗、细胞毒性药物和新型靶向药物在JNA复发中的作用。小型队列研究表明，放射治疗和氟他胺是残留和复发性JNA最合理的治疗选择。我们的综述强调了对原发性和复发性JNA管理进行进一步研究的必要性。
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