Quock R M, Sadowski J A
Pharmacol Res Commun. 1986 Jul;18(7):663-72. doi: 10.1016/0031-6989(86)90108-6.
In rats with unilateral electrolytic lesions of the substantia nigra, apomorphine induced ipsilateral rotational behavior that was significantly potentiated by naloxone. Yet, in rats with unilateral chemolytic (6-hydroxydopamine) lesions of the substantia nigra, apomorphine induced dose-dependent contralateral turning that was not influenced by pretreatment with even high doses of naloxone. High performance liquid chromatographic analysis of corpora striata from these rats revealed electrolytically-lesioned animals to have a 60-70% reduction in dopamine content while chemolytically-lesioned animals were virtually completely depleted of dopamine. These results suggest that striatal dopamine may be required for naloxone potentiation of apomorphine-induced effects in the rat rotational behavior paradigm.
在单侧黑质电解损伤的大鼠中，阿扑吗啡诱发同侧旋转行为，且纳洛酮能显著增强该行为。然而，在单侧黑质化学损伤（6-羟基多巴胺）的大鼠中，阿扑吗啡诱发剂量依赖性的对侧旋转，即使高剂量纳洛酮预处理也不会对其产生影响。对这些大鼠纹状体的高效液相色谱分析显示，电解损伤的动物多巴胺含量降低了60%-70%，而化学损伤的动物多巴胺几乎完全耗尽。这些结果表明，在大鼠旋转行为范式中，纹状体多巴胺可能是纳洛酮增强阿扑吗啡诱发效应所必需的。
