Hefti F, Melamed E, Sahakian B J, Wurtman R J
Pharmacol Biochem Behav. 1980 Feb;12(2):185-8. doi: 10.1016/0091-3057(80)90353-6.
Partial, unilateral lesions of the nigro-striatal tract were produced in rats by injecting various quantities of 6-hydroxydopamine into the substantia nigra. The extent of each animal's lesion was estimated by comparing tyrosine hydroxylase activities in its lesioned and control striata. L-DOPA and apomorphine induced contralateral (i.e., away from the lesion) circling behavior only in rats in which more than 90% of the nigro-striatal system had been destroyed. In contrast, d-amphetamine caused turning in the ipsilateral direction when as few as 50% of the nigro-striatal neurons had been destroyed.
通过向大鼠黑质注射不同剂量的6-羟基多巴胺，造成黑质-纹状体束的部分单侧损伤。通过比较每只动物损伤侧和对照侧纹状体中酪氨酸羟化酶的活性，来估计损伤的程度。左旋多巴和阿扑吗啡仅在黑质-纹状体系统90%以上被破坏的大鼠中诱导出对侧（即远离损伤侧）转圈行为。相比之下，当黑质-纹状体神经元仅有50%被破坏时，右旋苯丙胺就会引起同侧转动。
