N-乙酰半胱氨酸诱导的离体大鼠肝细胞脂质过氧化作用。
Lipid peroxidation induced by N-acetylcysteine in isolated rat hepatocytes.
作者信息
Dore M, Atzori L, Congiu L
出版信息
Pharmacol Res Commun. 1986 Aug;18(8):699-705. doi: 10.1016/0031-6989(86)90112-8.
PMID:3763676
Abstract
In isolated rat hepatocytes N-acetylcysteine induces an increase of lipid peroxidation, as evaluated by the malondialdehyde production and diene conjugation. Lipid peroxidation did not result in increased cell mortality. Antioxidants and free radicals scavengers completely protect toward lipid peroxidation induced by N-acetylcysteine.
摘要
在分离的大鼠肝细胞中，通过丙二醛生成和二烯结合评估，N-乙酰半胱氨酸可诱导脂质过氧化增加。脂质过氧化并未导致细胞死亡率增加。抗氧化剂和自由基清除剂可完全保护细胞免受N-乙酰半胱氨酸诱导的脂质过氧化作用。
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