Devasagayam T P, Tarachand U
Biochemistry Division, Bhabha Atomic Research Centre, Bombay, India.
Biochem Int. 1988 Jan;16(1):45-52.
A significant decrease in the hepatic malonaldehyde content and lipid peroxidation, induced by ascorbate, NADPH and cumene hydroperoxide, was observed during gestation in the rat. Lipid peroxidation tends to reach normal levels 3 days post partum. While a significant decrease in the lipid peroxidation of hepatic mitochondria was observed with ascorbate and NADPH, that of microsomes was affected by ascorbate and cumene hydroperoxide. The observed decrease in lipid peroxidation during pregnancy seems to be due to lesser phospholipid content, a lower degree of unsaturation in lipids, and an increase in the level of antioxidants.
在大鼠妊娠期观察到，抗坏血酸、烟酰胺腺嘌呤二核苷酸磷酸（NADPH）和氢过氧化异丙苯诱导的肝脏丙二醛含量及脂质过氧化显著降低。脂质过氧化在产后3天趋于达到正常水平。虽然抗坏血酸和NADPH可使肝脏线粒体脂质过氧化显著降低，但微粒体脂质过氧化受抗坏血酸和氢过氧化异丙苯影响。孕期观察到的脂质过氧化降低似乎是由于磷脂含量减少、脂质不饱和程度降低以及抗氧化剂水平升高所致。
