全球和区域口腔癌负担 1990 年至 2017 年：来自全球疾病负担研究的结果。

Global and regional burdens of oral cancer from 1990 to 2017: Results from the global burden of disease study.

机构信息

Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, 510632, P. R. China.

Department of Oral and Maxillofacial & Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, P. R. China.

出版信息

Cancer Commun (Lond). 2020 Mar;40(2-3):81-92. doi: 10.1002/cac2.12009. Epub 2020 Feb 18.

BACKGROUND

Data on the incidence, mortality, and other burden of oral cancer as well as their secular trends are necessary to provide policy-makers with the information needed to allocate resources appropriately. The purpose of this study was to use the Global Burden of Disease (GBD) 2017 results to estimate the incidence, mortality, and disability-adjusted life years (DALYs) for oral cancer from 1990 to 2017.

METHODS

We collected detailed data on oral cancer from 1990 to 2017 from the GBD 2017. The global incidence, mortality, and DALYs attributable to oral cancer as well as the corresponding age-standardized rates (ASRs) were calculated. The estimated annual percentage changes in the ASRs of incidence (ASRI) and mortality (ASRM) and age-standardized DALYs of oral cancer were also calculated according to regions and countries to quantify the secular trends in these rates.

RESULTS

We tracked the incidence, mortality, and DALYs of oral cancer in 195 countries/territories over 28 years. Globally, the incidence, mortality, and DALYs of oral cancer increased by about 1.0-fold from 1990 to 2017. The ASRI of oral cancer showed a similar trend, increasing from 4.41 to 4.84 per 100,000 person-years during the study period. The ASRM remained approximately stable at about 2.4 per 100,000 from 1990 to 2017, as did the age-standardized DALYs, at about 64.0 per 100,000 person-years. ASRI was highest in Pakistan (27.03/100,000, 95% CI = 22.13-32.75/100,000), followed by Taiwan China, and lowest in Iraq (0.96/100,000, 95% CI = 0.86-1.06/100,000). ASRM was highest in Pakistan (16.85/100,000, 95% CI = 13.92-20.17/100,000) and lowest in Kuwait (0.51/100,000, 95% CI = 0.45-0.58/100,000).

CONCLUSIONS

The ASRI of oral cancer has increased slightly worldwide, while the ASRM and age-standardized DALY have remained stable. However, these characteristics vary between countries, suggesting that current prevention strategies should be reoriented, and much more targeted and specific strategies should be established in some countries to forestall the increase in oral cancer.

背景

了解口腔癌的发病率、死亡率和其他负担，以及它们的时间趋势，对于为决策者提供适当分配资源所需的信息是必要的。本研究的目的是使用 2017 年全球疾病负担（GBD）的结果，来估计 1990 年至 2017 年口腔癌的发病率、死亡率和伤残调整生命年（DALYs）。

方法

我们从 2017 年 GBD 中收集了 1990 年至 2017 年口腔癌的详细数据。计算了口腔癌的全球发病率、死亡率和 DALYs，以及相应的年龄标准化率（ASR）。还根据区域和国家计算了口腔癌发病率（ASRI）和死亡率（ASRM）以及年龄标准化 DALYs 的估计年变化百分比，以量化这些比率的时间趋势。

结果

我们跟踪了 195 个国家/地区 28 年来的口腔癌发病率、死亡率和 DALYs。全球范围内，口腔癌的发病率、死亡率和 DALYs 在 1990 年至 2017 年间增加了约 1 倍。口腔癌的 ASRI 也呈现出类似的趋势，在研究期间从每 100,000 人年 4.41 增加到 4.84。1990 年至 2017 年间，口腔癌的 ASRM 基本保持稳定，约为每 100,000 人 2.4 例，年龄标准化的 DALYs 也基本保持稳定，约为每 100,000 人 64.0 例。巴基斯坦的 ASRI 最高（27.03/100,000，95%CI=22.13-32.75/100,000），其次是中国台湾，最低的是伊拉克（0.96/100,000，95%CI=0.86-1.06/100,000）。巴基斯坦的 ASRM 最高（16.85/100,000，95%CI=13.92-20.17/100,000），科威特的最低（0.51/100,000，95%CI=0.45-0.58/100,000）。