Du Xinwen, Mao Ling, Leng Yamei, Chen Fengjiao
Department of Hematology, West China Hospital/West China School of Nursing, Sichuan University, Chengdu, China.
Front Oncol. 2023 Aug 10;13:1183632. doi: 10.3389/fonc.2023.1183632. eCollection 2023.
It is essential to evaluate the quality of life in patients with hematologic malignancies to reflect the therapeutic effect and prognosis, but lengthy assessments are often burdensome. The 7-Item Functional Assessment of Cancer Therapy-General (FACT-G7) is a brief, easy, and rapid index for evaluating quality of life. Nevertheless, there is no report about its application in Chinese patients with hematologic malignancies.
The purpose of this study was to validate the Chinese version of the FACT-G7 for patients with hematologic malignancies.
This study is a cross-sectional study. A total of 855 patients with hematologic malignancies completed the Functional Assessment of Cancer Therapy-General (FACT-G) and were scored the Eastern Cooperative Oncology Group Performance Status (ECOG-PS) by nurses. Cronbach's alpha, confirmatory factor analyses, Pearson's correlation, and one-way analysis of variance were conducted to evaluate internal consistent reliability, structural validity and concurrent validity.
The FACT-G7 showed acceptable internal consistency, as indicated by a Cronbach's alpha of 0.73. The confirmatory factor analyses test for single-factor model fit for the FACT-G7 scale was almost adequate. The satisfactory correlations between the FACT-G7 and the FACT-G and its subscales, and ECOG-PS groups differed in FACT-G7 scores demonstrating concurrent validity.
This study suggested that the Chinese version of the FACT-G7 provides a useful and rapid measure for assessing quality of life in Chinese patients with hematologic malignancies, which providing a reference for further evaluation and care.
评估血液系统恶性肿瘤患者的生活质量对于反映治疗效果和预后至关重要，但冗长的评估往往负担较重。癌症治疗通用功能评估7项量表（FACT-G7）是一种简短、简便且快速的生活质量评估指标。然而，尚无关于其在中国血液系统恶性肿瘤患者中应用的报道。
本研究旨在验证FACT-G7中文版在血液系统恶性肿瘤患者中的有效性。
本研究为横断面研究。共855例血液系统恶性肿瘤患者完成了癌症治疗通用功能评估（FACT-G），护士对其进行了东部肿瘤协作组体能状态（ECOG-PS）评分。采用Cronbach's α系数、验证性因子分析、Pearson相关性分析和单因素方差分析来评估内部一致性信度、结构效度和效标效度。
FACT-G7显示出可接受的内部一致性，Cronbach's α系数为0.73。FACT-G7量表单因素模型拟合的验证性因子分析测试结果基本合适。FACT-G7与FACT-G及其子量表之间具有良好的相关性，且ECOG-PS组在FACT-G7评分上存在差异，表明具有效标效度。
本研究表明，FACT-G7中文版为评估中国血液系统恶性肿瘤患者的生活质量提供了一种有用且快速的测量方法，为进一步的评估和护理提供了参考。
