Zheng Bowen, Zhang Peng, Lv Qijun, Wu Tao, Liu Yadong, Tang Junjie, Ma Yanping, Cheng Lili, Xu Langtao, Wang Yizhen, Xue Yifan, Liu Jie, Ren Jie
Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangdong Province Key Laboratory of Hepatology Research, Multiple Disciplinary Team Center of Thyroid Diseases, No. 600, Tianhe Road, Guangzhou, Guangdong, 510630, PR China.
School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, No.66, Gongchang Road, Shenzhen, Guangdong, 518107, PR China.
Bioact Mater. 2023 Aug 12;31:119-135. doi: 10.1016/j.bioactmat.2023.08.010. eCollection 2024 Jan.
Image-guided thermal ablation (TA), which is less invasive, has been widely applied for treating various kinds of tumors. However, TA still poses the potential risk of thermal damage to sensitive tissue nearby. Therefore, an adjunctive thermoprotective hydrodissection technique with constant injection of 5% glucose (5% Glu) has currently been adopted for clinical application, but this may be hazardous to humans. In this study, a multifunctional hyaluronic acid-based hydrogel (HA-Dc) was developed for hydrodissection. Compared with 5% Glu (the most clinically used solution) and the previously reported F127 hydrogel, the HA-Dc hydrogel was studied in a porcine liver model and in a rabbit model and showed good injectability and better tissue retention, stability, and thermoprotective properties throughout the TA procedure. Furthermore, in the preclinical evaluation in a model, HA-Dc showed excellent performance in terms of stricter neuroprotection compared with 5% Glu. In addition, the HA-Dc hydrogel with good biocompatibility and controllable degradation behavior could be a promising platform for thermal protection during clinical TA procedures.
图像引导热消融（TA）具有微创性，已广泛应用于各种肿瘤的治疗。然而，TA仍存在对附近敏感组织造成热损伤的潜在风险。因此，目前临床上采用了持续注射5%葡萄糖（5% Glu）的辅助热保护水分离技术，但这可能对人体有害。在本研究中，开发了一种用于水分离的多功能透明质酸基水凝胶（HA-Dc）。与5% Glu（临床上最常用的溶液）和先前报道的F127水凝胶相比，在猪肝模型和兔模型中对HA-Dc水凝胶进行了研究，结果表明在整个TA过程中，HA-Dc水凝胶具有良好的可注射性以及更好的组织保留性、稳定性和热保护性能。此外，在一个模型的临床前评估中，与5% Glu相比，HA-Dc在更严格的神经保护方面表现出优异的性能。此外，具有良好生物相容性和可控降解行为的HA-Dc水凝胶可能是临床TA过程中热保护的一个有前景的平台。
