Li Xiying, Li Xiaojuan, Wang Xian, Yin Xuan, Li Shanshan, Wu Junyi, Ren Xiumei, Zhang Wei, Mi Yiqun, Xu Shifen
Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Integr Med Res. 2023 Sep;12(3):100974. doi: 10.1016/j.imr.2023.100974. Epub 2023 Jul 13.
We conducted this randomized controlled trial (RCT) to evaluate the effectiveness and safety of moxibustion at Sanyinjiao (SP6) acupoint for treatment of negative mood and sleep quality in healthcare workers during the 2019 coronavirus disease (COVID-19).
A total of 180 participants were divided in a 1:1 ratio into two groups, the treatment group (for moxibustion) and the control group (for no treatment). The treatment group had a 30-minute moxibustion therapy once a day for two weeks, followed by a two-week follow-up. The Hamilton Anxiety Scale (HAMA) was used to assess the degree of the participants' anxiety, and the Patient Health Questionnaire-9 (PHQ-9) was utilized to examine their depressed condition. The Maslach Burnout Inventory-General Survey (MBI-GS) was used to measure the level of burnout among healthcare workers. To determine the severity of insomnia, the Sleep Dysfunction Rating Scale (SDRS) was utilized. At baseline, week 2, and week 4, all scales were evaluated.
Compared to the control group, The treatment group improved more significantly in the HAMA at week 2 (MD = -19.01, 95% CI: -21.89 to -16.14; <0.001) and at week 4 follow-up visits (MD = -8.96, 95% CI: -11.19 to -6.73; <0.001). A subgroup study of HAMA scores revealed that position and education had significant impact on treatment effectiveness. During the 2-week intervention period, the treatment group showed more significant improvements in depressive symptoms measured by PHQ-9 (13.00±2.41 vs. 15.60±3.65; <0.001), work burnout symptoms measured by MBI-GS (MD = -11.88, 95% CI, -15.73 to -8.03; <0.001), and insomnia symptoms measured by SDRS (MD = -2.45, 95% CI, -4.24 to -0.66; <0.01). There were no significant adverse effects reported.
Moxibustion at SP6 may be an effective treatment to improve anxiety, depression, sleep quality, and quality of life for healthcare workers during COVID-19.
Chinese Clinical Trial Registry (ChiCTR): ChiCTR-2200059327.
我们开展了这项随机对照试验（RCT），以评估三阴交穴艾灸对2019冠状病毒病（COVID-19）期间医护人员负面情绪和睡眠质量的治疗效果及安全性。
共180名参与者按1:1比例分为两组，即治疗组（艾灸组）和对照组（不治疗组）。治疗组每天进行30分钟艾灸治疗，持续两周，之后进行两周随访。采用汉密尔顿焦虑量表（HAMA）评估参与者的焦虑程度，采用患者健康问卷-9（PHQ-9）检查其抑郁状况。采用马氏工作倦怠量表通用版（MBI-GS）测量医护人员的倦怠水平。使用睡眠功能障碍评定量表（SDRS）确定失眠的严重程度。在基线、第2周和第4周对所有量表进行评估。
与对照组相比，治疗组在第2周（MD = -19.01，95%CI：-21.89至-16.14；<0.001）和第4周随访时（MD = -8.96，95%CI：-11.19至-6.73；<0.001）的HAMA评分改善更为显著。HAMA评分的亚组研究表明，职位和学历对治疗效果有显著影响。在为期2周的干预期内，治疗组在PHQ-9测量的抑郁症状（13.00±2.41 vs. 15.60±3.65；<0.001）、MBI-GS测量的工作倦怠症状（MD = -11.88，95%CI，-15.73至-8.03；<0.001）以及SDRS测量的失眠症状（MD = -2.45，95%CI，-4.24至-0.66；<0.01）方面改善更为显著。未报告明显不良反应。
三阴交穴艾灸可能是改善COVID-19期间医护人员焦虑、抑郁、睡眠质量和生活质量的有效治疗方法。
中国临床试验注册中心（ChiCTR）：ChiCTR-2200059327。
