Department of Neurology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China.
School of Bioscience and Technology, Cengdu Medical College, Chengdu, China.
J Interv Cardiol. 2023 Aug 17;2023:9322188. doi: 10.1155/2023/9322188. eCollection 2023.
To evaluate the relationship between the plasma miR-223 expression level and clopidogrel resistance in acute coronary syndrome (ACS) patients.
We performed a search for publications using online databases including PubMed, EMBASE, Cochrane Library, and Chinese Databases (CNKI database, Weipu database, and Wanfang database) from the inception of the databases to June 18, 2023, to identify studies reporting the relationship between the plasma miR-223 level and clopidogrel resistance in ACS patients. Two researchers independently searched and screened to ensure the consistency of the results and assess the quality of the included studies according to the Newcastle-Ottawa scale. A fixed-effects model was used for pooling data with STATA 14.0.
Four articles including 399 Chinese ACS patients were eligible for the meta-analysis. Low plasma miR-223 levels were independently correlated with clopidogrel resistance in Chinese ACS patients (OR 0.58, 95% CI: 0.33-1.04).
Lower plasma miR-223 levels are associated with clopidogrel resistance in Chinese ACS patients, suggesting that miR-223 may be a potential diagnostic biomarker of clopidogrel resistance.
评估急性冠脉综合征（ACS）患者血浆 miR-223 表达水平与氯吡格雷抵抗之间的关系。
我们使用在线数据库（包括 PubMed、EMBASE、Cochrane 图书馆和中文数据库（CNKI 数据库、维普数据库和万方数据库））进行了文献检索，检索时间从数据库建立到 2023 年 6 月 18 日，以确定报告 ACS 患者血浆 miR-223 水平与氯吡格雷抵抗之间关系的研究。两位研究人员独立搜索和筛选，以确保结果的一致性，并根据 Newcastle-Ottawa 量表评估纳入研究的质量。使用 STATA 14.0 采用固定效应模型进行数据合并。
四项研究包括 399 例中国 ACS 患者符合荟萃分析标准。低血浆 miR-223 水平与中国 ACS 患者氯吡格雷抵抗独立相关（OR 0.58，95%CI：0.33-1.04）。
较低的血浆 miR-223 水平与中国 ACS 患者的氯吡格雷抵抗相关，提示 miR-223 可能是氯吡格雷抵抗的潜在诊断生物标志物。
