Graca Mateusz, Sarantopoulos Konstantinos, Horn Danielle Bodzin
Department of Anesthesiology, Rush University Medical Center, Chicago, IL, United States.
Department of Anesthesiology, Perioperative Medicine and Pain Medicine, University of Miami Miller School of Medicine, Miami, FL, United States.
Front Toxicol. 2023 Aug 10;5:1188152. doi: 10.3389/ftox.2023.1188152. eCollection 2023.
Chronic ocular pain is a common, debilitating chronic pain condition with significant morbidity and negative impact in patients' quality of life. Several, diverse types of insults to the ocular surface can lead to acute, and under certain conditions to chronic ocular pain, and these include toxic irritants. Exposure of ocular surface to toxic irritants, in addition to direct tissue injury, carries the capacity to generated intense immune and neuronal responses with hyper-excitability, sensitization and chronic pain. Because, chronic ocular pain subsequent to toxic exposures is relatively unrecognized clinical entity, this brief review highlights pertinent concepts of its epidemiology, pathogenesis/pathophysiology, clinical progression, with recommendations for its clinical management that clinicians may find helpful. Suppression of pain signaling, generating neuronal sensitization, and prevention of chronicity of neuropathic pain is particularly emphasized in this respect.
慢性眼痛是一种常见的、使人衰弱的慢性疼痛病症，具有较高的发病率，并对患者的生活质量产生负面影响。眼表受到多种不同类型的损伤可导致急性眼痛，在某些情况下还会导致慢性眼痛，其中包括有毒刺激物。眼表暴露于有毒刺激物，除了直接的组织损伤外，还能够引发强烈的免疫和神经元反应，伴有过度兴奋、致敏和慢性疼痛。由于有毒物质暴露后引发的慢性眼痛是一种相对未被认识的临床病症，本简要综述重点介绍了其流行病学、发病机制/病理生理学、临床进展的相关概念，并提出了临床管理建议，临床医生可能会觉得这些建议很有帮助。在这方面，特别强调了抑制疼痛信号、产生神经元致敏以及预防神经性疼痛的慢性化。
