Jeraiby Mohammed A
Department of Medical Biochemistry, Faculty of Medicine, Jazan University, Jazan, SAU.
Cureus. 2023 Jul 26;15(7):e42522. doi: 10.7759/cureus.42522. eCollection 2023 Jul.
Comorbidities including leukemia are risk factors in coronavirus disease 2019 (COVID-19) patients for high morbidity and mortality. The severity of the disease is usually correlated with lymphopenia. On the other hand, we came across a case of marked absolute lymphocytosis in a COVID-19 patient, which further escalated five-fold during his hospital stay. Subsequently, the diagnosis of chronic lymphocytic leukemia (CLL) was made following positive cell surface markers for CD19+, CD5+, and CD20+ (dim), in the presence of restricted immunoglobulin light chain of lambda type on flow cytometry. Numerous cases are available in the literature of COVID-19 among established CLL patients. However, we are mentioning here the second case where the diagnosis of CLL was established accidentally during the work-up for lymphocytosis in COVID-19 infection.
包括白血病在内的合并症是2019冠状病毒病（COVID-19）患者高发病率和死亡率的风险因素。该疾病的严重程度通常与淋巴细胞减少相关。另一方面，我们遇到了一例COVID-19患者出现明显的绝对淋巴细胞增多症，在其住院期间进一步升高了五倍。随后，在流式细胞术检测中发现细胞表面标记物CD19 +、CD5 +和CD20 +（弱阳性）呈阳性，且存在λ型限制性免疫球蛋白轻链，从而确诊为慢性淋巴细胞白血病（CLL）。文献中有许多已确诊CLL患者感染COVID-19的病例。然而，我们在此提及的是第二例在COVID-19感染淋巴细胞增多症检查过程中意外确诊CLL的病例。
