铁状态和微量营养素与儿童造血系统恶性肿瘤贫血的相关性：来自印度北部的一项研究。
Correlation of Iron Status and Micronutrients With Anaemia of Childhood Haematopoietic Malignancies: A Study From Northern India.
作者信息
Tripathi Archana, Singh Monika, Jaiswal Mamta, Singh Dezy, Kumar Arvind, Hatwal Deepa
机构信息
Department of Blood Bank, Baba Raghav Das Medical College, Gorakhpur, IND.
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
出版信息
Cureus. 2023 Jul 25;15(7):e42438. doi: 10.7759/cureus.42438. eCollection 2023 Jul.
BACKGROUND
Most cancer patients undergoing chemotherapy develop anemia during their course of treatment. There is a need for early treatment for chemotherapy-induced anemia to prevent morbidity and mortality.
MATERIAL AND METHOD
This is a hospital-based study, conducted over one year and included 59 children who are known cases of hematological malignancy aged up to 18 years. Standard methods were used to measure micronutrients and complete blood count. Statistical analysis was done using SPSS for Windows, Version 15.0 (Released 2006; SPSS Inc., Chicago, United States).
RESULTS
The majority of subjects (n=21; 35.6%) were aged six to nine years with male dominance. Micronutrient deficiency and significant anemia were noted in 40-50% and 64.4% of cases, respectively. Both malignancy and blood indices showed no association with micronutrients.
CONCLUSION
Anemia with micronutrient deficiency is common in children with hematopoietic malignancies receiving chemotherapy. However, no significant association was noted between red cell indices and levels of micronutrients.
背景
大多数接受化疗的癌症患者在治疗过程中会出现贫血。需要对化疗引起的贫血进行早期治疗，以预防发病和死亡。
材料与方法
这是一项基于医院的研究，为期一年，纳入了59名年龄在18岁以下的血液系统恶性肿瘤已知病例的儿童。采用标准方法测量微量营养素和全血细胞计数。使用SPSS for Windows 15.0版（2006年发布；SPSS公司，美国芝加哥）进行统计分析。
结果
大多数受试者（n = 21；35.6%）年龄在6至9岁，以男性为主。分别有40 - 50%和64.4%的病例存在微量营养素缺乏和显著贫血。恶性肿瘤和血液指标均与微量营养素无关联。
结论
接受化疗的血液系统恶性肿瘤儿童中，贫血伴微量营养素缺乏很常见。然而，红细胞指标与微量营养素水平之间未发现显著关联。
Zotero 插件