Demir Cengiz, Demir Halit, Esen Ramazan, Sehitogullari Abidin, Atmaca Murat, Alay Murat
Department of Hematology, Medical Faculty Yuzuncu Yil University, Turkey.
Asian Pac J Cancer Prev. 2011;12(12):3471-4.
The purpose of the study was to compare serum concentrations of some elements [zinc (Zn), copper (Cu), manganese (Mn), magnesium (Mg), lead (Pb), iron (Fe), cadmium (Cd) and cobalt (Co)] in acute leukemia patients with those of healthy subjects.
The study group consisted of newly diagnosed acute leukemia patients and the controls were matched for socioeconomic stauts and eating habits. The elements levels in the patient group were measured before treatment with an atomic absorption spectrophotometer. The selection criteria for the patients and controls were the lack of recent blood transfusion history and taking any medication with mineral supplement.
The acute leukemia group composed of 42 patients and there were 40 persons in the control group. There was no difference between the age of the two groups (p=0.239). Serum levels of Zn, Mg and Mn were significantly lower with acute leukemia than in controls (p<0.001, p=0.011, p<0.001, respectively), while Cu, Pb and Cd were significantly elevated (p=0.003, p<0.001, p<0.001, respectively). There were no significant differences regarding Co and Fe (p=0.323 and p=0.508, respectively)
In this study, we found levels of Zn, Mg and Mn to be lowered and of Cu, Pb and Cd to be elevated in patients with leukemia. Further studies are needed to clarify the role of these elements in pathogenesis of acute leukemia.
本研究旨在比较急性白血病患者与健康受试者血清中某些元素[锌（Zn）、铜（Cu）、锰（Mn）、镁（Mg）、铅（Pb）、铁（Fe）、镉（Cd）和钴（Co）]的浓度。
研究组由新诊断的急性白血病患者组成，对照组在社会经济地位和饮食习惯方面进行了匹配。用原子吸收分光光度计在治疗前测定患者组的元素水平。患者和对照组的选择标准是近期无输血史且未服用任何含矿物质补充剂的药物。
急性白血病组由42例患者组成，对照组有40人。两组年龄无差异（p = 0.239）。急性白血病患者血清中Zn、Mg和Mn水平显著低于对照组（分别为p < 0.001、p = 0.011、p < 0.001），而Cu、Pb和Cd显著升高（分别为p = 0.003、p < 0.001、p < 0.001）。Co和Fe无显著差异（分别为p = 0.323和p = 0.508）。
在本研究中，我们发现白血病患者的Zn、Mg和Mn水平降低，Cu、Pb和Cd水平升高。需要进一步研究以阐明这些元素在急性白血病发病机制中的作用。
