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一名跨性别女性氨氯地平过量：病例报告

Amlodipine Overdose in a Transgender Woman: A Case Study.

作者信息

Bojja Srikaran, Javed Nismat, Bojja Shreya, Itare Vikram, Nasr Rabih

机构信息

Internal Medicine, BronxCare Health System/Icahn School of Medicine at Mount Sinai, New York, USA.

Medicine, Malla Reddy Institute of Medical Sciences, Hyderabad, IND.

出版信息

Cureus. 2023 Jul 26;15(7):e42511. doi: 10.7759/cureus.42511. eCollection 2023 Jul.

DOI:10.7759/cureus.42511
PMID:37637641
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10457432/
Abstract

Calcium channel blockers are a major cause of cardiovascular toxicity. The clinical spectrum of these patients is very variable and there is no consensus on the dose required for toxicity. We present a case of a 43-year-old transgender woman who presented with hypotension and tachycardia owing to drug overdose that was later confirmed to be amlodipine. Given the catastrophic cascade of events involved with such toxicities, it is important to highlight amlodipine as one of the causes of drug overdose that can be overlooked.

摘要

钙通道阻滞剂是心血管毒性的主要原因。这些患者的临床症状差异很大，对于中毒所需剂量也没有共识。我们报告一例43岁的跨性别女性病例，该患者因药物过量出现低血压和心动过速，后来证实过量药物为氨氯地平。鉴于此类毒性所涉及的一系列灾难性事件，重要的是要强调氨氯地平是药物过量的一个可能被忽视的原因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/10457432/7b9a19dda018/cureus-0015-00000042511-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/10457432/b64e12d92c42/cureus-0015-00000042511-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/10457432/91f2345fd688/cureus-0015-00000042511-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/10457432/7b9a19dda018/cureus-0015-00000042511-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/10457432/b64e12d92c42/cureus-0015-00000042511-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/10457432/91f2345fd688/cureus-0015-00000042511-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/788a/10457432/7b9a19dda018/cureus-0015-00000042511-i03.jpg

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1
Amlodipine Overdose in a Transgender Woman: A Case Study.一名跨性别女性氨氯地平过量：病例报告
Cureus. 2023 Jul 26;15(7):e42511. doi: 10.7759/cureus.42511. eCollection 2023 Jul.
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Case records of the Massachusetts General Hospital. Case 24-2006. A 40-year-old woman with hypotension after an overdose of amlodipine.马萨诸塞州总医院病例记录。病例24 - 2006。一名40岁女性，服用过量氨氯地平后出现低血压。
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本文引用的文献

1
Use of extracorporeal membrane oxygenation in massive amlodipine overdose.体外膜肺氧合在大剂量氨氯地平中毒中的应用。
Arch Toxicol. 2022 Dec;96(12):3403-3405. doi: 10.1007/s00204-022-03364-5. Epub 2022 Aug 20.
2
Refractory Shock from Amlodipine Overdose Overcomed with Hyperinsulinemia.氨氯地平过量致难治性休克，用高胰岛素血症克服。
Cardiovasc Toxicol. 2022 Jan;22(1):63-66. doi: 10.1007/s12012-021-09699-2. Epub 2021 Oct 13.
3
Severe Amlodipine Toxicity: A Case Rescued with Extracorporeal Membrane Oxygenation.严重氨氯地平中毒：一例通过体外膜肺氧合救治的病例
Indian J Crit Care Med. 2020 May;24(5):365-366. doi: 10.5005/jp-journals-10071-23423.
4
The unknown known: non-cardiogenic pulmonary edema in amlodipine poisoning, a cohort study.阿洛地平中毒所致非心源性肺水肿的未知之知：一项队列研究。
Clin Toxicol (Phila). 2020 Nov;58(11):1042-1049. doi: 10.1080/15563650.2020.1725034. Epub 2020 Mar 2.
5
An Overview of Hyperinsulinemic-Euglycemic Therapy in Calcium Channel Blocker and β-blocker Overdose.钙通道阻滞剂和β受体阻滞剂过量时的高胰岛素-正常血糖治疗概述。
Pharmacotherapy. 2018 Nov;38(11):1130-1142. doi: 10.1002/phar.2177. Epub 2018 Oct 4.
6
Amlodipine (150 mg) Poisoning: A Case Study.氨氯地平（150毫克）中毒：病例研究
Curr Drug Saf. 2018;13(2):144-147. doi: 10.2174/1574886313666180313120659.
7
The potential detrimental effects of calcium channel blockers' overdose and current available management.钙通道阻滞剂过量的潜在有害影响及当前可用的处理方法。
Ann Transl Med. 2018 Jan;6(1):16. doi: 10.21037/atm.2018.01.03.
8
A Fatal Case of Amlodipine Toxicity Following Iatrogenic Hypercalcemia.氨氯地平中毒致致命病例：医源性高钙血症。
Cardiovasc Toxicol. 2018 Jun;18(3):290-293. doi: 10.1007/s12012-018-9445-3.
9
A Case of Severe, Refractory Hypotension After Amlodipine Overdose.氨氯地平过量致严重难治性低血压 1 例
Cardiovasc Toxicol. 2018 Apr;18(2):192-197. doi: 10.1007/s12012-017-9419-x.
10
Shock due to amlodipine overdose.氨氯地平过量导致的休克。
Indian J Crit Care Med. 2013 Nov;17(6):375-7. doi: 10.4103/0972-5229.123452.