服用红曲补充剂后横纹肌溶解诱导的急性肾损伤：一例报告。
Rhabdomyolysis-induced acute kidney injury after administration of a red yeast rice supplement: A case report.
作者信息
Wang Ya-Han, Zhang Si-Shuo, Li Hai-Tao, Zhi Hong-Wei, Wu Hong-Yun
机构信息
Department of Neurology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China.
出版信息
World J Clin Cases. 2023 Aug 16;11(23):5547-5553. doi: 10.12998/wjcc.v11.i23.5547.
BACKGROUND
A few reports have revealed induction of rhabdomyolysis by a red yeast rice (RYR) supplement or by RYR in combination with abiraterone (an androgen biosynthesis inhibitor).
CASE SUMMARY
A 76-year-old man presented with progressive limb weakness, muscle soreness, and acute kidney injury (AKI). He had been taking the anti-prostate cancer drug abiraterone for 14 mo and had added a RYR supplement 3 mo before symptom onset. After being diagnosed with rhabdomyolysis-induced AKI, the patient discontinued these drugs and responded well to hemodialysis and hemoperfusion. After 23 d of treatment, creatine kinase levels returned to normal and serum creatinine levels decreased.
CONCLUSION
We speculate that statins, the main lipid-lowering component of RYR, or a combination of statins and abiraterone, will increase the risk of rhabdomyolysis.
背景
有几份报告显示，红曲米（RYR）补充剂或RYR与阿比特龙（一种雄激素生物合成抑制剂）联合使用可诱发横纹肌溶解。
病例摘要
一名76岁男性出现进行性肢体无力、肌肉酸痛和急性肾损伤（AKI）。他服用抗前列腺癌药物阿比特龙已14个月，并在症状出现前3个月开始添加RYR补充剂。在被诊断为横纹肌溶解诱发的AKI后，患者停用了这些药物，并对血液透析和血液灌流反应良好。治疗23天后，肌酸激酶水平恢复正常，血清肌酐水平下降。
结论
我们推测，RYR的主要降脂成分他汀类药物，或他汀类药物与阿比特龙的组合，会增加横纹肌溶解的风险。
Zotero 插件