Department of Cell Biology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Chongqing, China.
Department of Wound Infection and Drug, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, China.
Front Immunol. 2023 Aug 10;14:1236923. doi: 10.3389/fimmu.2023.1236923. eCollection 2023.
Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor that produced IFN-I and regulated innate immune response, subsequent studies have revealed that IRF7 performs a multifaceted and versatile functions in multiple biological processes. In this review, we provide a comprehensive overview on the current knowledge of the role of IRF7 in immunity and autoimmunity. We focus on the latest regulatory mechanisms of IRF7 in IFN-I, including signaling pathways, transcription, translation, and post-translational levels, the dimerization and nuclear translocation, and the role of IRF7 in IFN-III and COVID-19. In addition to antiviral immunity, we also discuss the role and mechanism of IRF7 in autoimmunity, and the further research will expand our understanding of IRF7.
干扰素调节因子 (IRF) 7 最初被鉴定为产生 IFN-I 和调节先天免疫反应的主要转录因子，随后的研究表明，IRF7 在多种生物学过程中具有多方面和多功能的作用。在这篇综述中，我们提供了关于 IRF7 在免疫和自身免疫中的作用的最新知识的全面概述。我们重点介绍了 IFN-I 中 IRF7 的最新调节机制，包括信号通路、转录、翻译和翻译后水平、二聚化和核易位，以及 IRF7 在 IFN-III 和 COVID-19 中的作用。除了抗病毒免疫外，我们还讨论了 IRF7 在自身免疫中的作用和机制，进一步的研究将扩展我们对 IRF7 的理解。
