Li Kun, Li Long, Wang Jie
Department of Clinical Laboratory Medicine, Suining Central Hospital, Suining, Sichuan, People's Republic of China.
Infect Drug Resist. 2023 Aug 22;16:5463-5471. doi: 10.2147/IDR.S423660. eCollection 2023.
This study aimed to investigate the antibiotic resistance patterns and clinical distribution of blood culture-positive isolates at Suining Central Hospital between 2018 and 2021. The findings of this study can provide a basis for ensuring rational and effective use of antibiotic therapy in clinical settings.
This retrospective study analyzed the data of 3660 non-repeating strains that tested positive for clinical blood culture, collected from the microbiology laboratory of Suining Central Hospital between January 2018 and December 2021. The identification of bacterial species and their antibiotic resistance patterns were analyzed.
The study found that 76.7% of the bacterial strains identified were Gram-negative bacteria, while 23.3% were Gram-positive bacteria. (44.8%), spp. (19.2%), (9.2%), spp. (5.3%), and spp. were the top five bacterial ratios observed. These bacteria were detected most frequently in the Digestion Center, intensive care unit (ICU), Neurology Center, Urology Department, and Hematology Department. Among the spp., methicillin-resistant (MRSA) and methicillin-resistant (MRCNS) were detected at rates of 39.3% and 71.8%, respectively. However, no vancomycin- or linezolid-resistant staphylococci were identified. showed higher susceptibility to most antibiotic than , except for tetracycline. The resistance rates of and spp. to meropenem and imipenem were low, but the resistance rates for other antibiotic were above 40%.
The results of this study show a rising incidence of bacterial antibiotic resistance in positive blood culture specimens at Suining Central Hospital. Clinicians should carefully consider the importance of blood culture antibiotic susceptibility testing to ensure effective treatment. The Department of Microbiology at Suining Central Hospital should regularly analyze the distribution of pathogenic bacteria and antibiotic resistance in blood cultures to ensure the most effective treatment possible.
本研究旨在调查2018年至2021年遂宁市中心医院血培养阳性分离株的抗生素耐药模式及临床分布情况。本研究结果可为临床合理、有效地使用抗生素治疗提供依据。
本回顾性研究分析了2018年1月至2021年12月从遂宁市中心医院微生物实验室收集的3660株临床血培养阳性的非重复菌株的数据。分析了细菌种类鉴定及其抗生素耐药模式。
研究发现，鉴定出的细菌菌株中76.7%为革兰氏阴性菌，23.3%为革兰氏阳性菌。（44.8%）、 spp.（19.2%）、 （9.2%）、 spp.（5.3%）和 spp.是观察到的前五大细菌比例。这些细菌在消化中心、重症监护病房（ICU）、神经中心、泌尿外科和血液科检测最为频繁。在 spp.中，耐甲氧西林 （MRSA） 和耐甲氧西林 （MRCNS） 的检出率分别为39.3%和71.8%。然而，未鉴定出耐万古霉素或耐利奈唑胺的葡萄球菌。 对大多数抗生素的敏感性高于 ，四环素除外。 spp.和 spp.对美罗培南和亚胺培南的耐药率较低，但对其他抗生素的耐药率高于40%。
本研究结果表明，遂宁市中心医院血培养阳性标本中细菌抗生素耐药率呈上升趋势。临床医生应认真考虑血培养抗生素敏感性检测的重要性，以确保有效治疗。遂宁市中心医院微生物科应定期分析血培养中病原菌的分布及抗生素耐药情况，以确保尽可能有效的治疗。
