Van An Nguyen, Hoang Le Huy, Le Hai Ha Long, Thai Son Nguyen, Hong Le Thu, Viet Tien Tran, Le Tuan Dinh, Thang Ta Ba, Vu Luong Huy, Nguyen Vinh Thi Ha, Xuan Nguyen Kien
Department of Microbiology, Military Hospital 103, Vietnam Military Medical University, Hanoi, Vietnam.
Department of Bacteriology, National of Hygiene and Epidemiology, Hanoi, Vietnam.
Infect Drug Resist. 2023 Mar 23;16:1677-1692. doi: 10.2147/IDR.S402278. eCollection 2023.
Studies on the epidemiology of bloodstream infection (BSI) and antimicrobial resistance (AMR) are limited in Vietnam. Thus, the present study aimed to elucidate the epidemiology of BSI and AMR of BSI-causing bacteria in Vietnam.
Data regarding blood cultures from 2014 to 2021 were collected and analyzed using the chi-square test, Cochran-Armitage test, and binomial logistic regression model.
Overall, 2405 (14.15%) blood cultures were positive during the study period. In total, 55.76% of BSIs occurred in patients aged ≥60 years. The male-to-female ratio of patients with BSI was 1.87:1. (26.11%), (15.79%), (10.44%), (4.70%), and (3.45%) were the leading bacterial species causing BSI. The AMR rate of these bacteria isolated in the intensive care unit (ICU) was significantly higher compared with that of those in other wards. was the least resistant to carbapenems (2.39%-4.14%), amikacin (3.85%), and colistin (11.54%) and most resistant to penicillins (>80.0%). was the least resistant to glycopeptides (0%-3.38%), quinupristin-dalfopristin (0.59%), and linezolid (1.02%) and most resistant to clindamycin (71.57%). was the least resistant to ertapenem (8.86%), amikacin (9.39%), and colistin (15.38%) and most resistant to aztreonam (83.33%). was the least resistant to amikacin (16.67%) and colistin (16.67%) and highly resistant to other antibiotics (≥50.0%). was the least resistant to colistin (16.33%) and piperacillin (28.17%) and highly resistant to other antibiotics (≥50.0%). Notably, the multidrug resistance rate of (76.41%) was the highest among common pathogens, followed by (71.57%), (64.56%), (56.99%), and (43.72%).
The AMR rate of BSI-causing bacteria, particularly strains isolated from ICU, was alarmingly high. There is a need for new antibiotics, therapeutic strategies, as well as prevention and control to combat BSI and AMR.
越南关于血流感染（BSI）流行病学及抗菌药物耐药性（AMR）的研究有限。因此，本研究旨在阐明越南BSI的流行病学及引起BSI细菌的AMR情况。
收集2014年至2021年血培养数据，并采用卡方检验、 Cochr an - Armitage检验和二项逻辑回归模型进行分析。
总体而言，研究期间2405份（14.15%）血培养呈阳性。总计，55.76%的BSI发生在年龄≥60岁的患者中。BSI患者的男女比例为1.87:1。（26.11%）、（15.79%）、（10.44%）、（4.70%）和（3.45%）是引起BSI的主要细菌种类。在重症监护病房（ICU）分离出的这些细菌的AMR率显著高于其他病房。对碳青霉烯类药物耐药性最低（2.39% - 4.14%）、对阿米卡星耐药率为（3.85%）、对多粘菌素耐药率为（11.54%），对青霉素耐药性最高（>80.0%）。对糖肽类药物耐药性最低（0% - 3.38%）、对奎奴普丁 - 达福普汀耐药率为（0.59%）、对利奈唑胺耐药率为（1.02%），对克林霉素耐药性最高（71.57%）。对厄他培南耐药性最低（8.86%）、对阿米卡星耐药率为（9.39%）、对多粘菌素耐药率为（15.38%），对氨曲南耐药性最高（83.33%）。对阿米卡星耐药率最低（16.67%）、对多粘菌素耐药率为（16.67%），对其他抗生素耐药性高（≥50.0%）。对多粘菌素耐药性最低（16.33%）、对哌拉西林耐药率为（28.17%），对其他抗生素耐药性高（≥50.0%）。值得注意的是，在常见病原体中，（76.41%）的多重耐药率最高，其次是（71.57%）、（64.56%）、（56.99%）和（43.72%）。
引起BSI细菌的AMR率，尤其是从ICU分离出的菌株，高得惊人。需要新的抗生素、治疗策略以及预防和控制措施来对抗BSI和AMR。
