Frasier Kelly M, Gallagher-Poehls Caroline, Cochrane Mikayla, Roy Debosree
Public Health, AT Still University - School of Osteopathic Medicine, Mesa, USA.
Public Health, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, USA.
Cureus. 2023 Aug 25;15(8):e44119. doi: 10.7759/cureus.44119. eCollection 2023 Aug.
While the acute phase of the COVID-19 pandemic has largely come to pass, the chronic physiologic effects of the coronavirus continue to unfold. Specifically, the number of COVID-19-associated vasculitis cases has steadily increased since the onset of the pandemic. Data have shown that vasculitis may develop less than two weeks after COVID-19 or during a later onset of the disease. At this time, research has demonstrated that the novel coronavirus invades more than just the lungs; it can also attack the nervous system, cardiovascular system, and kidneys. In addition, there is a greater understanding of the pathogenesis regarding COVID-19-induced vasculitis via humoral immunity and immune complex disease. Recent case reports have shown an association between COVID-19 and secondary vasculitis. This review paper discusses case reports and data that suggest that COVID-19 may lead to specific vasculitis diseases such as giant cell arteritis, ophthalmic arteritis, aortitis, and Kawasaki-like disease. More research needs to be performed on this association to aid in diagnosis and treatment.
虽然新冠疫情的急性期在很大程度上已经过去，但冠状病毒的慢性生理影响仍在不断显现。具体而言，自疫情爆发以来，与新冠相关的血管炎病例数量一直在稳步增加。数据显示，血管炎可能在感染新冠后不到两周内出现，也可能在疾病后期出现。目前，研究表明这种新型冠状病毒不仅侵袭肺部；它还会攻击神经系统、心血管系统和肾脏。此外，人们对新冠病毒通过体液免疫和免疫复合物疾病引发血管炎的发病机制有了更深入的了解。最近的病例报告显示了新冠与继发性血管炎之间的关联。这篇综述文章讨论了病例报告和数据，这些报告和数据表明新冠可能导致特定的血管炎疾病，如巨细胞动脉炎、眼动脉炎、主动脉炎和川崎样疾病。需要对这种关联进行更多研究，以辅助诊断和治疗。
