Losito Attilio
Renal Unit, Ospedale Santa Maria Della Misericordia, Piazzale Menghini, Perugia, Italy.
Clin Kidney J. 2023 Feb 6;16(6):891-895. doi: 10.1093/ckj/sfad024. eCollection 2023 Jun.
It is known to few that the path to the discovery of the long-denied plasma creatinine and its clearance was long and difficult. For quite a long time, related controversies between different groups of researchers were widespread and heated. The scientists who have dealt with the related problems are among the most famous of the last century and some of them are part of the history of medicine. Giovanni Ferro-Luzzi, an Italian clinician, was one of these researchers. He was among the first to detect and dose plasma creatinine and the first ever to measure the clearance of endogenous creatinine (CrCl). Unfortunately, due to a series of unforeseeable events, he has been completely forgotten together with his undertakings. In this review we retrace the steps that led to the measurement of plasma creatinine, and CrCl. With brief biographical notes we try to explain the oblivion of this important figure and of his nephrological accomplishments.
鲜为人知的是，发现长期被忽视的血肌酐及其清除率的道路漫长而艰难。在相当长的一段时间里，不同研究团队之间的相关争议广泛且激烈。处理这些相关问题的科学家都是上世纪最著名的科学家之一，其中一些人还载入了医学史册。意大利临床医生乔瓦尼·费罗 - 卢齐就是这些研究人员之一。他是最早检测和测定血肌酐的人之一，也是有史以来第一个测量内生肌酐清除率（CrCl）的人。不幸的是，由于一系列不可预见的事件，他连同他的事业一起被完全遗忘了。在这篇综述中，我们追溯了导致血肌酐和CrCl测量的各个步骤。通过简短的传记笔记，我们试图解释这位重要人物及其肾脏学成就被遗忘的原因。
