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[眼科中的纳米技术]

[Nanotechnologies in ophthalmology].

作者信息

Gusev A A, Zakharova O V, Vasyukova I A, Osmanov R E, Al-Makhdar Ya M

机构信息

Tambov State University named after G.R. Derzhavin, Tambov, Russia.

National University of Science and Technology (MISIS), Moscow, Russia.

出版信息

Vestn Oftalmol. 2023;139(4):107-114. doi: 10.17116/oftalma2023139041107.

Abstract

Application of new materials and methods in the diagnosis and treatment of eye diseases is one of the promising research areas in modern ophthalmology. Significant progress has been made in understanding the pathogenesis, diagnosis and treatment of eye diseases using nanotechnologies and nanomaterials. This paper presents the main achievements and results of original research on this issue. It has been shown that nanoparticles are able to overcome biological barriers, deliver drugs to the target site, and provide the required drug release rate. Modern nanotechnological approaches in tissue engineering are also being actively introduced into ophthalmology, making it possible to create nanoframeworks for growing three-dimensional cellular structures, including arrays of pigment epithelium cells and retinal ganglion cells for the treatment of retinal damage caused by degenerative diseases, injuries and infections.

摘要

新材料和方法在眼科疾病诊断与治疗中的应用是现代眼科学中一个有前景的研究领域。利用纳米技术和纳米材料在理解眼科疾病的发病机制、诊断和治疗方面已取得显著进展。本文介绍了关于该问题的原创性研究的主要成果。研究表明,纳米颗粒能够克服生物屏障,将药物输送到靶位点,并提供所需的药物释放速率。组织工程中的现代纳米技术方法也正被积极引入眼科学,使得创建用于生长三维细胞结构的纳米框架成为可能,包括用于治疗由退行性疾病、损伤和感染引起的视网膜损伤的色素上皮细胞阵列和视网膜神经节细胞阵列。

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