Yuzuncu Yıl University Medical Faculty Department of Ophthalmology, Goz Hastaliklari AD, Van 65080, Turkey.
Yeni Yuzyil University Medical Faculty Department of Ophthalmology, Istanbul, Turkey.
Photodiagnosis Photodyn Ther. 2023 Dec;44:103773. doi: 10.1016/j.pdpdt.2023.103773. Epub 2023 Aug 26.
To compare ocular findings of acromegaly patients with healthy individuals and investigate the relation of serum levels of insulin-like growth factor (IGF-1) along with growth hormone (GH) and pituitary tumor (adenoma) dimensions (TD) with specific ocular parameters.
The ocular parameters of acromegaly patients (n = 38) were compared with those of healthy subjects (n = 36). These parameters were intraocular pressure, keratometric (K1-K2) values, central corneal thickness (CCT), total axial length along with anterior chamber-lens-vitreous length, retinal nerve fiber layer (RNFL) thickness, central foveal thickness (CFT), choroidal thickness (CT), ganglion cell layer thickness (GCLT), and inner plexiform layer thickness (IPLT). Also investigated was whether there was a correlation between disease duration, TD, GH, IGF-I, CCT, RNFL, CFT, GCLT, IPLT, and CT.
The lens length of the acromegaly group was increased (p = 0.014). GH and IGF-1 levels were positively correlated with CT and CCT, respectively (p = 0.041, r = 0.343) (p = 0.03, r = 0.347). Analysis of TD also found a highly negative correlation with the mean RNFL thickness of the acromegaly patients (p < 0.01, r = -0.603). The mean value of the inner parts of GCLT and IPLT was negatively correlated with TD (p = 0.041, r = -0.343 and p = 0.025, r = -0.379, respectively).
Serum IGF-1 and GH levels might be determinant factors in CCT and CT, respectively. The pituitary adenoma size increasing may be prone to lead RNFL, ganglion cell layer, inner plexiform layer thinning. Increased lens thickness was found in the acromegaly group.
比较肢端肥大症患者与健康个体的眼部发现，并研究血清胰岛素样生长因子 (IGF-1) 水平以及生长激素 (GH) 和垂体肿瘤 (腺瘤) 直径 (TD) 与特定眼部参数的关系。
将肢端肥大症患者 (n=38) 的眼部参数与健康受试者 (n=36) 的眼部参数进行比较。这些参数包括眼压、角膜曲率 (K1-K2) 值、中央角膜厚度 (CCT)、总眼轴长度以及前房-晶状体-玻璃体长度、视网膜神经纤维层 (RNFL) 厚度、中央视网膜厚度 (CFT)、脉络膜厚度 (CT)、神经节细胞层厚度 (GCLT) 和内丛状层厚度 (IPLT)。还研究了疾病持续时间、TD、GH、IGF-I、CCT、RNFL、CFT、GCLT、IPLT 和 CT 之间是否存在相关性。
肢端肥大症组的晶状体长度增加 (p=0.014)。GH 和 IGF-1 水平分别与 CT 和 CCT 呈正相关 (p=0.041，r=0.343)(p=0.03，r=0.347)。TD 分析还发现与肢端肥大症患者的平均 RNFL 厚度呈高度负相关 (p<0.01，r=-0.603)。GCLT 和 IPLT 内部平均值与 TD 呈负相关 (p=0.041，r=-0.343 和 p=0.025，r=-0.379，分别)。
血清 IGF-1 和 GH 水平可能分别是 CCT 和 CT 的决定因素。垂体腺瘤大小的增加可能容易导致 RNFL、神经节细胞层、内丛状层变薄。在肢端肥大症组中发现晶状体厚度增加。
