University of Health Sciences Turkey, Faculty of Medicine School of Medicine, Istanbul Sisli Hamidiye Etfal Health Training and Research Hospital, Clinic of Endocrinology and Metabolism, Sisli/Istanbul, Turkey.
University of Health Sciences Turkey, Faculty of Medicine School of Medicine, Istanbul Sisli Hamidiye Etfal Health Training and Research Hospital, Clinic of Ophthalmology, Sisli/Istanbul, Turkey.
Photodiagnosis Photodyn Ther. 2021 Dec;36:102590. doi: 10.1016/j.pdpdt.2021.102590. Epub 2021 Oct 18.
We aimed to investigate the retinal layers and macular capillary structure using optical coherence tomography angiography (OCTA) with acromegaly patients and determine the relationship between OCTA parameters and disease duration, Growth hormone (GH) and Insuline growth factor (IGF - 1) levels.
Twenty-two patients with acromegaly who were followed up in the endocrinology outpatient clinic of Sisli Hamidiye Etfal Health Training and Research Hospital, were recruited into the study. Healthy control group was consisted of 22 age and gender matched subjects. Complete opthalmological examination including best visual acuity (BCVA), axial lenght, intraocular pressure (IOP) measurement, anterior segment and fundus examination, central corneal thickness with pachymetry and OCTA measurement were performed in the patients and healthy control group. Foveal avascular zone (FAZ), foveal vascular density (FVD), parafoveal vascular density (PFVD), choroidal flow (CF), foveal thickness (FT) and choroidal thickness (CT) were compared beetwen groups. Correlation between disease duration, GH and IGF-1 levels and OCTA parameters were evaluated.
There was no statistically significant difference between the groups in terms of BCVA, axial length, IOP, FT, FAZ, FD and PFVD. Choroidal thickness and CF was significantly high in the patients group compared to healthy controls (respectively, p = 0.003, p = 0.022). The mean follow-up period in patients with acromegaly was 90±50.2 months. There was a significant correlation between GH and subfoveal choroidal thickness in the patient group (p < 0.001, r = 0.52), a significant correlation was determined between disease duration and corneal thickness (p = 0.01, r = 0.41). In addition, an inverse correlation was detected between the IGF-1 level and the FAZ domain (p = 0.022, r= -0.34).
In patients with acromegaly, choroidal vasculature seems to be more affected than the retinal vasculature.
我们旨在通过光学相干断层扫描血管造影术（OCTA）研究肢端肥大症患者的视网膜层和黄斑毛细血管结构，并确定 OCTA 参数与疾病持续时间、生长激素（GH）和胰岛素样生长因子 1（IGF-1）水平之间的关系。
本研究纳入了 22 例在 Sisli Hamidiye Etfal 健康培训和研究医院内分泌科门诊随访的肢端肥大症患者，并将其纳入研究。健康对照组由 22 名年龄和性别匹配的受试者组成。对患者和健康对照组进行了全面的眼科检查，包括最佳视力（BCVA）、眼轴长度、眼压（IOP）测量、眼前段和眼底检查、中央角膜厚度和 OCTA 测量。比较两组间的中心凹无血管区（FAZ）、中心凹血管密度（FVD）、旁中心凹血管密度（PFVD）、脉络膜血流（CF）、中心凹厚度（FT）和脉络膜厚度（CT）。评估疾病持续时间、GH 和 IGF-1 水平与 OCTA 参数之间的相关性。
两组在 BCVA、眼轴长度、IOP、FT、FAZ、FD 和 PFVD 方面无统计学差异。与健康对照组相比，患者组的脉络膜厚度和 CF 显著升高（分别为 p=0.003，p=0.022）。肢端肥大症患者的平均随访时间为 90±50.2 个月。在患者组中，GH 与亚中心凹脉络膜厚度之间存在显著相关性（p<0.001，r=0.52），疾病持续时间与角膜厚度之间存在显著相关性（p=0.01，r=0.41）。此外，还检测到 IGF-1 水平与 FAZ 域之间呈负相关（p=0.022，r=-0.34）。
在肢端肥大症患者中，脉络膜血管似乎比视网膜血管更受影响。
