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滥用合成代谢类固醇导致肺出血和广泛的动脉血栓形成。

Pulmonary haemorrhage and extensive arterial thrombosis with anabolic steroid abuse.

机构信息

Internal Medicine, HCA MidAmerica DIvision, Kansas City, Kansas, USA.

Hematology and Medical Oncology, Albert Einstein College of Medicine D Samuel Gottesman Library, Bronx, New York, USA

出版信息

BMJ Case Rep. 2023 Aug 27;16(8):e254817. doi: 10.1136/bcr-2023-254817.

Abstract

Anabolic-androgenic steroids (AASs) are commonly implicated in thromboembolic events but rarely cause diffuse alveolar haemorrhage. We report the case of a Caucasian man in his late 40s who was consuming supratherapeutic doses of AAS and presented with shortness of breath and haemoptysis. Chest imaging showed bilateral patchy infiltrates in the lungs with diffuse blood throughout the airways on bronchoscopy. Extensive infectious and autoimmune workup were unremarkable. The patient then developed right foot ischaemia and was found to have extensive aortic and bilateral lower extremity arterial thrombosis. Anticoagulation was attempted despite haemoptysis. Thrombectomy procedures were unsuccessful and the patient eventually developed worsening rhabdomyolysis requiring intubation and bilateral amputation. His clinical condition continued to worsen and he passed away 10 days after admission. This case highlights the rare synchronous occurrence of two life-threatening complications secondary to anabolic steroid abuse which can pose a significant diagnostic and therapeutic challenge for clinicians.

摘要

合成代谢雄激素类固醇(AAS)通常与血栓栓塞事件有关,但很少引起弥漫性肺泡出血。我们报告了一例 40 多岁的高加索男性,他服用了超治疗剂量的 AAS,出现呼吸急促和咯血。胸部影像学显示肺部双侧斑片状浸润,支气管镜检查显示气道内弥漫性出血。广泛的感染和自身免疫检查无明显异常。随后,该患者出现右脚缺血,并发现广泛的主动脉和双侧下肢动脉血栓形成。尽管有咯血,仍尝试进行抗凝治疗。血栓切除术均未成功,患者最终出现进行性横纹肌溶解症,需要插管和双侧截肢。他的临床状况持续恶化,入院后 10 天死亡。本病例强调了由于滥用合成代谢类固醇而导致的两种危及生命的并发症同时发生的罕见情况,这对临床医生构成了重大的诊断和治疗挑战。

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本文引用的文献

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A case of steroid-induced diffuse alveolar hemorrhage.一例类固醇诱导的弥漫性肺泡出血。
Lung India. 2018 Nov-Dec;35(6):532-533. doi: 10.4103/lungindia.lungindia_206_18.
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Pulmonary hemorrhage following anabolic agent abuse: Two cases.合成代谢药物滥用后发生的肺出血:两例报告。
Respir Med Case Rep. 2016 Apr 13;18:45-7. doi: 10.1016/j.rmcr.2016.04.001. eCollection 2016.
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[Alveolar hemorrhage].[肺泡出血]
Rev Mal Respir. 2015 Apr;32(4):394-412. doi: 10.1016/j.rmr.2014.11.066. Epub 2015 Apr 16.
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Diffuse alveolar hemorrhage.弥漫性肺泡出血
Tuberc Respir Dis (Seoul). 2013 Apr;74(4):151-62. doi: 10.4046/trd.2013.74.4.151. Epub 2013 Apr 30.

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