Parrot A, Fartoukh M, Cadranel J
Service de réanimation, hôpital Tenon, AP-HP, 75020 Paris, France; Centre expert en oncologie thoracique et de compétence en maladies rares, service de pneumologie, hôpital Tenon, AP-HP, 75020 Paris, France.
Service de réanimation, hôpital Tenon, AP-HP, 75020 Paris, France; Centre expert en oncologie thoracique et de compétence en maladies rares, service de pneumologie, hôpital Tenon, AP-HP, 75020 Paris, France; Université Pierre-et-Marie-Curie, Paris 06, France.
Rev Mal Respir. 2015 Apr;32(4):394-412. doi: 10.1016/j.rmr.2014.11.066. Epub 2015 Apr 16.
Alveolar hemorrhage occurs relatively rarely and is a therapeutic emergency because it can quickly lead to acute respiratory failure, which can be fatal. Hemoptysis associated with anemia and pulmonary infiltrates suggest the diagnosis of alveolar hemorrhage, but may be absent in one third of cases including patients in respiratory distress. The diagnosis of alveolar hemorrhage is based on the findings of a bronchoalveolar lavage. The causes are numerous. It is important to identify alveolar hemorrhage due to sepsis, then separate an autoimmune cause (vasculitis associated with antineutrophil cytoplasmic antibody, connective tissue disease and Goodpasture's syndrome) with the search for autoantibodies and biopsies from readily accessible organs, from a non-immune cause, performing echocardiography. Lung biopsy should be necessary only in exceptional cases. If the hemorrhage has an immune cause, treatment with steroids and cyclophosphamide may be started. The indications for treatment with rituximab are beginning to be established (forms that are not severe and refractory forms). The benefit of plasma exchange is unquestionable in Goodpasture's syndrome. In patients with an immune disease that can lead to an alveolar hemorrhage, removing any source of infection is the first priority.
肺泡出血相对少见,是一种治疗急症,因为它可迅速导致急性呼吸衰竭,而这可能是致命的。咯血伴贫血和肺部浸润提示肺泡出血的诊断,但在包括呼吸窘迫患者在内的三分之一的病例中可能不存在。肺泡出血的诊断基于支气管肺泡灌洗的结果。病因众多。识别由败血症引起的肺泡出血很重要,然后通过寻找自身抗体和对易于获取的器官进行活检,将自身免疫性病因(与抗中性粒细胞胞浆抗体相关的血管炎、结缔组织病和古德帕斯彻综合征)与非免疫性病因区分开来,后者需进行超声心动图检查。仅在特殊情况下才需要进行肺活检。如果出血有免疫性病因,可开始使用类固醇和环磷酰胺治疗。利妥昔单抗的治疗适应证正在开始确立(非严重形式和难治性形式)。血浆置换在古德帕斯彻综合征中的益处是毋庸置疑的。对于可能导致肺泡出血的免疫性疾病患者,消除任何感染源是首要任务。