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[人乳头瘤病毒相关口咽鳞状细胞癌的诊断与治疗研究进展]

[Research progress in diagnosis and treatment of HPV-associated oropharyngeal squamous cell carcinoma].

作者信息

He Meilin, Yi Junlin

机构信息

Department of Radiation Oncology National Cancer Center/ National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,China.

出版信息

Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Sep;37(9):734-739. doi: 10.13201/j.issn.2096-7993.2023.09.009.

DOI:10.13201/j.issn.2096-7993.2023.09.009
PMID:37640996
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10722117/
Abstract

Oropharyngeal carcinoma is one of the most common malignant tumors of head and neck. In recent years, the incidence of Human papilloma virus-associated oropharyngeal squamous cell carcinoma(HPV-OPSCC) has been increasing year by year. With the advancement of minimally invasive surgical techniques, the wide application of intensity modulated radiation therapy, and the demand of patients for organ function protection and higher quality of life, the unique biological behavior and better prognosis of HPV-OPSCC have led to the exploration of a series of attenuated treatment modes. This article reviews the diagnosis and treatment status of oropharyngeal cancer and related research progress based on relevant reports.

摘要

口咽癌是头颈部最常见的恶性肿瘤之一。近年来,人乳头瘤病毒相关的口咽鳞状细胞癌(HPV-OPSCC)的发病率逐年上升。随着微创外科技术的进步、调强放射治疗的广泛应用以及患者对器官功能保护和更高生活质量的需求,HPV-OPSCC独特的生物学行为和较好的预后促使人们探索一系列减量化的治疗模式。本文基于相关报道对口咽癌的诊治现状及相关研究进展进行综述。

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[Research progress in diagnosis and treatment of HPV-associated oropharyngeal squamous cell carcinoma].[人乳头瘤病毒相关口咽鳞状细胞癌的诊断与治疗研究进展]
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本文引用的文献

1
Long-Term Toxic Effects, Swallow Function, and Quality of Life on MC1273: A Phase 2 Study of Dose De-escalation for Adjuvant Chemoradiation in Human Papillomavirus-Positive Oropharyngeal Cancer.MC1273的长期毒性作用、吞咽功能及生活质量:一项关于人乳头瘤病毒阳性口咽癌辅助放化疗剂量递减的2期研究
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Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial.评估 HPV 相关口咽鳞状细胞癌放疗降阶梯治疗与经口手术治疗的毒性效应和生存情况:ORATOR2 期随机临床试验。
JAMA Oncol. 2022 Jun 1;8(6):1-7. doi: 10.1001/jamaoncol.2022.0615.
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Evaluation of Substantial Reduction in Elective Radiotherapy Dose and Field in Patients With Human Papillomavirus-Associated Oropharyngeal Carcinoma Treated With Definitive Chemoradiotherapy.评估人乳头瘤病毒相关口咽癌患者接受根治性放化疗后选择性放疗剂量和野减少的情况。
JAMA Oncol. 2022 Mar 1;8(3):364-372. doi: 10.1001/jamaoncol.2021.6416.
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Randomized Trial of Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Long-Term Results of the ORATOR Trial.随机对照试验:放疗对比经口机器人手术治疗口咽鳞癌:ORATOR 试验的长期结果。
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Phase II Randomized Trial of Transoral Surgery and Low-Dose Intensity Modulated Radiation Therapy in Resectable p16+ Locally Advanced Oropharynx Cancer: An ECOG-ACRIN Cancer Research Group Trial (E3311).可切除 p16+局部晚期口咽癌的经口手术联合低剂量调强放疗的 II 期随机试验:一项 ECOG-ACRIN 癌症研究组试验(E3311)。
J Clin Oncol. 2022 Jan 10;40(2):138-149. doi: 10.1200/JCO.21.01752. Epub 2021 Oct 26.
6
Randomized Trial of Radiation Therapy With Weekly Cisplatin or Cetuximab in Low-Risk HPV-Associated Oropharyngeal Cancer (TROG 12.01) - A Trans-Tasman Radiation Oncology Group Study.随机对照试验:低危型 HPV 相关口咽癌的放疗联合每周顺铂或西妥昔单抗治疗(TROG 12.01)——一项跨塔斯曼放射肿瘤学组研究。
Int J Radiat Oncol Biol Phys. 2021 Nov 15;111(4):876-886. doi: 10.1016/j.ijrobp.2021.04.015. Epub 2021 Jun 4.
7
Reduced-Dose Radiation Therapy for HPV-Associated Oropharyngeal Carcinoma (NRG Oncology HN002).HPV 相关口咽癌的低剂量放疗(NRG 肿瘤学 HN002)。
J Clin Oncol. 2021 Mar 20;39(9):956-965. doi: 10.1200/JCO.20.03128. Epub 2021 Jan 28.
8
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.口腔、喉、口咽和下咽鳞状细胞癌:EHNS-ESMO-ESTRO诊断、治疗及随访临床实践指南
Ann Oncol. 2020 Nov;31(11):1462-1475. doi: 10.1016/j.annonc.2020.07.011. Epub 2020 Oct 23.
9
Comparison of Survival After Transoral Robotic Surgery vs Nonrobotic Surgery in Patients With Early-Stage Oropharyngeal Squamous Cell Carcinoma.经口机器人手术与非机器人手术治疗早期口咽鳞状细胞癌患者的生存比较。
JAMA Oncol. 2020 Oct 1;6(10):1555-1562. doi: 10.1001/jamaoncol.2020.3172.
10
Human papillomavirus (HPV) in Chinese oropharyngeal squamous cell carcinoma (OPSCC): A strong predilection for the tonsil.人乳头瘤病毒(HPV)与中国口咽鳞状细胞癌(OPSCC):强烈倾向于扁桃体。
Cancer Med. 2020 Sep;9(18):6556-6564. doi: 10.1002/cam4.3339. Epub 2020 Jul 27.