Zhao Shuqi, Han Zhengxue
Department of Oral and Maxillofacial-Head and Neck Oncology，Capital Medical University School of Stomatology，Beijing，100050，China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2023 Sep;37(9):740-747. doi: 10.13201/j.issn.2096-7993.2023.09.010.
The number of new cases of oropharyngeal cancer is increasing year by year among the world, and HPV infection is one of the risk factors for this malignant tumor. Compared with HPV-negative oropharyngeal cancer, HPV-positive patients are more sensitive to radiotherapy and have a better prognosis, but there is no accepted treatment for HPV-positive patients. Reducing treatment intensity moderately and exploring the best option to minimize side effects of treatment are urgent issues to be addressed. This article reviews the research progress on the treatment improvement of HPV-associated oropharyngeal cancer in recent years.
在全球范围内，口咽癌的新发病例数逐年增加，人乳头瘤病毒（HPV）感染是这种恶性肿瘤的危险因素之一。与HPV阴性的口咽癌相比，HPV阳性患者对放疗更敏感，预后更好，但目前尚无针对HPV阳性患者的公认治疗方案。适度降低治疗强度并探索将治疗副作用降至最低的最佳方案是亟待解决的问题。本文综述了近年来HPV相关口咽癌治疗改善方面的研究进展。
