Affiliated Nanjing Brain Hospital of Nanjing Medical University, No.264 Guangzhou Street, Gulou District, Nanjing, 210029, Jiangsu, China.
Cognitive Behavioral Therapy Institute of Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
BMC Psychiatry. 2023 Aug 28;23(1):628. doi: 10.1186/s12888-023-05082-3.
Patients with remitted major depressive disorder (rMDD) show abnormal functional connectivity of the central executive network (CEN), salience networks (SN) and default mode network (DMN). It is unclear how these change during remission, or whether changes are related to function.
Three spatial networks in 17 patients with rMDD were compared between baseline and the six-month follow-up, and to 22 healthy controls. Correlations between these changes and psychosocial functioning were also assessed.
In the CEN, patients at baseline had abnormal functional connectivity in the right anterior cingulate, right dorsolateral prefrontal cortex (DLPFC) and inferior parietal lobule (IPL) compare with HCs. There were functional connection differences in the right DLPFC and left IPL at baseline during follow-up. Abnormal connectivity in the right DLPFC and medial prefrontal cortex (mPFC) were found at follow-up. In the SN, patients at baseline had abnormal functional connectivity in the insula, left anterior cingulate, left IPL, and right precuneus; compared with baseline, patients had higher connectivity in the right DLPFC at follow-up. In the DMN, patients at baseline had abnormal functional connectivity in the right mPFC. Resting-state functional connectivity of the IPL and DLPFC in the CEN correlated with psychosocial functioning.
At six-month follow-up, the CEN still showed abnormal functional connectivity in those with rMDD, while anomalies in the SN and DMN has disappeared. Resting-state functional connectivity of the CEN during early rMDD is associated with psychosocial function.
Pharmacotherapy and Psychotherapy for MDD after Remission on Psychology and Neuroimaging. https://www.
gov/ , registration number: NCT01831440 (15/4/2013).
缓解期的重度抑郁症（rMDD）患者的中央执行网络（CEN）、突显网络（SN）和默认模式网络（DMN）的功能连接异常。目前尚不清楚这些在缓解期内如何变化，或者这些变化是否与功能有关。
比较了 17 名 rMDD 患者在基线和六个月随访时与 22 名健康对照组之间的三个空间网络。还评估了这些变化与心理社会功能的相关性。
在 CEN 中，与 HCs 相比，患者在基线时右侧前扣带回、右侧背外侧前额叶皮层（DLPFC）和下顶叶小叶（IPL）的功能连接异常。在随访期间，右侧 DLPFC 和左侧 IPL 在基线时有功能连接差异。在随访时发现右侧 DLPFC 和内侧前额叶皮层（mPFC）的连接异常。在 SN 中，患者在基线时右侧岛叶、左侧前扣带回、左侧 IPL 和右侧楔前叶的功能连接异常；与基线相比，患者在随访时右侧 DLPFC 的连接增加。在 DMN 中，患者在基线时右侧 mPFC 的功能连接异常。CEN 中 IPL 和 DLPFC 的静息状态功能连接与心理社会功能相关。
在六个月的随访中，rMDD 患者的 CEN 仍显示出异常的功能连接，而 SN 和 DMN 的异常已经消失。rMDD 早期 CEN 的静息状态功能连接与心理社会功能相关。
心理神经影像学缓解后对 MDD 的药物治疗和心理治疗。https://www.clinicaltrials.gov/ ，注册号：NCT01831440（2013 年 4 月 15 日）。
