School of Psychology, Nanjing Normal University, Nanjing, China; Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing, China.
Psychology center, Nanjing University of Posts and Telecommunications, Nanjing, China.
Compr Psychiatry. 2020 Oct;102:152204. doi: 10.1016/j.comppsych.2020.152204. Epub 2020 Aug 20.
The recovery of psychosocial functioning is an important treatment goal for patients with depression. The aim of the present study is to investigate psychosocial functioning restoration 1 year after major depressive disorder (MDD) remission.
Depression symptoms and psychosocial functioning were assessed in 167 remitted MDD patients at baseline, as well as 1, 2, 6, 9, and 12 months following remission, according to the Hamilton Depression Scale (HAMD-17) and Generic Quality of Life Inventory (GQOLI-74).
Of the 167 MDD patients, 85 completed the final evaluation at 1 year, 32 relapsed, and 50 dropped out. The total relapse rate over 1 year was 27%. A rapid increase in psychosocial functioning was found in the first 2 months after remission in the non-relapse group. In the non-relapse group, psychosocial functioning was higher at 2 months than at baseline. At baseline and 2 months, psychosocial functioning was lower in the relapse group patients compared to those in the non-relapse group.
Patients with MDD showed continuous improvement in psychosocial functioning during the first year after remission, though psychosocial functioning in the relapse group remained the same during the first two months, suggesting possible further relapse.
心理社会功能的恢复是抑郁症患者的重要治疗目标。本研究旨在探讨重度抑郁症（MDD）缓解后 1 年的心理社会功能恢复情况。
根据汉密尔顿抑郁量表（HAMD-17）和一般生活质量量表（GQOLI-74），在缓解后基线、第 1、2、6、9 和 12 个月，对 167 例缓解后的 MDD 患者进行抑郁症状和心理社会功能评估。
167 例 MDD 患者中，85 例完成了 1 年的最终评估，32 例复发，50 例脱落。1 年内总复发率为 27%。在缓解后 2 个月内，未复发组的心理社会功能迅速增加。在未复发组中，2 个月时的心理社会功能高于基线。在基线和 2 个月时，复发组患者的心理社会功能低于未复发组。
MDD 患者在缓解后 1 年内心理社会功能持续改善，但复发组在前两个月心理社会功能保持不变，提示可能进一步复发。
