Liu C Y, Zhang X M, Yue H F, Shi Y X
The First Clinical Medical College of Shanxi Medical University, Taiyuan 030001, China.
Shanxi Eye Hospital Affiliated to Shanxi Medical University, Taiyuan 030002, China.
Zhonghua Yan Ke Za Zhi. 2023 Nov 11;59(11):948-953. doi: 10.3760/cma.j.cn112142-20230627-00246.
Müller cells are important glial cells in the retina, which play important roles in maintaining the stability of the retina by mechanical support, homeostasis, and physiological metabolism, as well as protecting photoreceptor cells and retinal pigment epithelial cells. The degeneration and destruction of Müller cells are often accompanied by various retinal diseases, and the function of Müller cells is changed under pathological conditions. Based on the summary of the morphology, distribution and function of Müller cells, this article analyzes the different manifestations and changes of Müller cells in different stages of macular hole and the closely related mechanisms, aiming to clarify the role of Müller cells in the formation and development of macular hole and to provide reference for the prediction of disease progression and guidance of treatment.(This article was published ahead of print on the official website of Chinese Journal of Ophthalmology on Augest 28, 2023).
Müller细胞是视网膜中重要的神经胶质细胞，通过机械支持、内环境稳定和生理代谢在维持视网膜稳定性方面发挥重要作用，同时保护光感受器细胞和视网膜色素上皮细胞。Müller细胞的变性和破坏常伴有各种视网膜疾病，且在病理条件下其功能会发生改变。本文在总结Müller细胞的形态、分布和功能的基础上，分析了黄斑裂孔不同阶段Müller细胞的不同表现及变化以及与之密切相关的机制，旨在阐明Müller细胞在黄斑裂孔形成和发展中的作用，为疾病进展的预测和治疗指导提供参考。（本文于2023年8月28日在中国眼科杂志官网提前在线发表）
