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The association of DNA methylation at birth with adolescent asthma is mediated by atopy.出生时的DNA甲基化与青少年哮喘之间的关联是由特应性介导的。
Clin Exp Allergy. 2023 Nov;53(11):1226-1229. doi: 10.1111/cea.14386. Epub 2023 Aug 28.
2
Different implications of paternal and maternal atopy for perinatal IgE production and asthma development.父系和母系特应性对围产期IgE产生及哮喘发展的不同影响。
Clin Dev Immunol. 2012;2012:132142. doi: 10.1155/2012/132142. Epub 2012 Jan 9.
3
Epidemiologic study of the genetics and environment of asthma, bronchial hyperresponsiveness, and atopy.哮喘、支气管高反应性和特应性的遗传学与环境的流行病学研究
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4
Atopy and asthma: an epidemic of unknown cause.特应性与哮喘：一种病因不明的流行病。
J Allergy Clin Immunol. 2005 Jul;116(1):231-2; author reply 232. doi: 10.1016/j.jaci.2005.03.008.
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Allelic frequencies and patterns of single-nucleotide polymorphisms in candidate genes for asthma and atopy in Iceland.冰岛哮喘和特应性候选基因中的等位基因频率及单核苷酸多态性模式
Am J Respir Crit Care Med. 2001 Dec 1;164(11):2036-44. doi: 10.1164/ajrccm.164.11.2101086.
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EGEA (Epidemiological study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy)--design issues. EGEA Co-operative Group.EGEA（哮喘、支气管高反应性和特应性的遗传学与环境流行病学研究）——设计问题。EGEA合作小组
Clin Exp Allergy. 1995 Nov;25 Suppl 2:19-22. doi: 10.1111/j.1365-2222.1995.tb00413.x.
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Atopy, allergy and the alimentary canal.特应性、过敏与消化道。
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Expression Quantitative Trait Methylation Analysis Reveals Methylomic Associations With Gene Expression in Childhood Asthma.表达数量性状甲基化分析揭示了儿童哮喘中甲基组与基因表达的关联。
Chest. 2020 Nov;158(5):1841-1856. doi: 10.1016/j.chest.2020.05.601. Epub 2020 Jun 20.
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[ANALYSIS OF HLA II GENES IN RELATION TO ATOPIC AND NONATOPIC ASTHMA IN AN UZBEK POPULATION].[乌兹别克人群中与特应性和非特应性哮喘相关的HLA II类基因分析]
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Do all asthmatics with atopy have atopic asthma?所有患有特应性的哮喘患者都患有特应性哮喘吗？
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引用本文的文献

1
Prenatal ambient air pollution associations with DNA methylation in asthma- and allergy-relevant genes: findings from ECHO.产前环境空气污染与哮喘和过敏相关基因DNA甲基化的关联：ECHO研究结果
Environ Epigenet. 2025 May 28;11(1):dvaf013. doi: 10.1093/eep/dvaf013. eCollection 2025.

本文引用的文献

1
DNA Methylation and Asthma Acquisition during Adolescence and Post-Adolescence, an Epigenome-Wide Longitudinal Study.DNA甲基化与青少年期及青少年后期哮喘的发生：一项全表观基因组纵向研究
J Pers Med. 2022 Feb 2;12(2):202. doi: 10.3390/jpm12020202.
2
Sex-specific associations of asthma acquisition with changes in DNA methylation during adolescence.青春期 DNA 甲基化变化与哮喘发病的性别特异性关联。
Clin Exp Allergy. 2021 Feb;51(2):318-328. doi: 10.1111/cea.13776. Epub 2020 Nov 25.
3
Maternal atopy and offspring epigenome-wide methylation signature.母体过敏与后代表观基因组全甲基化特征。
Epigenetics. 2021 Jun;16(6):629-641. doi: 10.1080/15592294.2020.1814504. Epub 2020 Sep 9.
4
Cohort Profile: The Isle Of Wight Whole Population Birth Cohort (IOWBC).队列简介：怀特岛全人群出生队列（IOWBC）。
Int J Epidemiol. 2018 Aug 1;47(4):1043-1044i. doi: 10.1093/ije/dyy023.
5
Multigenerational cohorts in patients with asthma and allergy.哮喘和过敏患者的多代队列研究。
J Allergy Clin Immunol. 2017 Feb;139(2):415-421. doi: 10.1016/j.jaci.2016.12.002.
6
Epidemiology and natural history of atopic diseases.特应性疾病的流行病学与自然史
Eur Clin Respir J. 2015 Mar 24;2. doi: 10.3402/ecrj.v2.24642. eCollection 2015.
7
DNA methylation loci associated with atopy and high serum IgE: a genome-wide application of recursive Random Forest feature selection.与特应性和高血清IgE相关的DNA甲基化位点：递归随机森林特征选择在全基因组中的应用
Genome Med. 2015 Aug 21;7(1):89. doi: 10.1186/s13073-015-0213-8.
8
DNA methylation arrays as surrogate measures of cell mixture distribution.DNA 甲基化芯片作为细胞混合物分布的替代测量指标。
BMC Bioinformatics. 2012 May 8;13:86. doi: 10.1186/1471-2105-13-86.

The association of DNA methylation at birth with adolescent asthma is mediated by atopy.

作者信息

Rathod Aniruddha, Melaram Rajesh, Zhang Hongmei, Arshad Hasan, Ewart Susan, Ray Meredith, Relton Caroline L, Karmaus Wilfried, Holloway John W

机构信息

Peter O'Donnell Jr School of Public Health, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Division of Epidemiology, Biostatistics and Environmental Health, School of Public Health, University of Memphis, Memphis, Tennessee, USA.

出版信息

Clin Exp Allergy. 2023 Nov;53(11):1226-1229. doi: 10.1111/cea.14386. Epub 2023 Aug 28.

DOI:10.1111/cea.14386
PMID:37641502
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10840950/
Abstract
摘要