Ali Abuzer, Ali Amena, Warsi Musarrat Husain, Ahmad Wasim, Amir Mohd, Abdi Sayed Aliul Hasan
Department of Pharmacognosy, College of Pharmacy, Taif University, P.O. Box 11099, 21944 Taif, Saudi Arabia.
Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, 21944 Taif, Saudi Arabia.
3 Biotech. 2023 Sep;13(9):318. doi: 10.1007/s13205-023-03726-5. Epub 2023 Aug 26.
(DC) stapf. (Gramineae) is a herb known worldwide as lemongrass. The oil obtained, i.e., lemongrass oil has emerged as one among the most relevant natural oils in the pharmaceutical industry owing to its extensive pharmacological and therapeutic benefits including antioxidant, antimicrobial, antiviral and anticancer properties. However, its usage in novel formulations is constrained because of its instability and volatility. To address these concerns, the present study aims to formulate lemongrass-loaded SLN (LG) using hot water titration technique. In the , Tween 80 was selected as a surfactant component, while ethanol was taken as a co-surfactant. Different ratios of (1:1, 1:2, 1:3, 2:1 and 3:1) were utilized to formulate LG-loaded SLN. The results indicated the fact that the LG formulation (abbreviated as LG), containing lipid phase 10% w/w (i.e., LG 3.33% and SA 6.67%), Tween 80 (20% w/w), ethanol (20% w/w) and distilled water (50% w/w), revealed suitable nanometric size (142.3 ± 5.96 nm) with a high zeta potential value (- 29.12 ± 1.7 mV) and a high entrapment efficiency (77.02 ± 8.12%). A rapid drug release (71.65 ± 5.33%) was observed for LG in a time span of 24 h. Additionally, the highest values for steady-state flux (; 0.6133 ± 0.0361 mg/cm/h), permeability coefficient (; 0.4573 ± 0.0141 (cm/h) × 10) and enhancement ratio (; 13.50) was also conferred by LG. Based on in vitro study results, the developed SLN appeared as a potential carrier for enhanced topical administration of lemongrass oil. The observed results also indicated the fact that the phyto-cosmeceutical prospective of the nanolipidic carrier for topical administration of lemongrass oil utilizing pharmaceutically acceptable components can be explored further for widespread clinical applicability.
The online version contains supplementary material available at 10.1007/s13205-023-03726-5.
禾本科植物香茅（DC）stapf.是一种在全球范围内被称为柠檬草的草本植物。所提取的油，即柠檬草油，因其广泛的药理和治疗益处，包括抗氧化、抗菌、抗病毒和抗癌特性，已成为制药行业中最相关的天然油之一。然而，由于其不稳定性和挥发性，它在新型制剂中的应用受到限制。为了解决这些问题，本研究旨在采用热水滴定技术制备负载柠檬草的固体脂质纳米粒（LG）。在实验中，选择吐温80作为表面活性剂成分，乙醇作为助表面活性剂。利用不同比例（1:1、1:2、1:3、2:1和3:1）来制备负载LG的固体脂质纳米粒。结果表明，LG制剂（简称为LG），含有10% w/w的脂质相（即LG 3.33%和SA 6.67%）、吐温80（20% w/w）、乙醇（20% w/w）和蒸馏水（50% w/w），具有合适的纳米尺寸（142.3±5.96 nm），高zeta电位值（-29.12±1.7 mV）和高包封率（77.02±8.12%）。在24小时的时间跨度内观察到LG有快速的药物释放（71.65±5.33%）。此外，LG还具有最高的稳态通量值（；0.6133±0.0361 mg/cm/h）、渗透系数值（；0.4573±0.0141（cm/h）×10）和增强比值（；13.50）。基于体外研究结果，所开发的固体脂质纳米粒似乎是一种用于增强柠檬草油局部给药的潜在载体。观察结果还表明，利用药学上可接受的成分将纳米脂质载体用于柠檬草油局部给药的植物化妆品前景可进一步探索，以实现广泛的临床应用。
在线版本包含可在10.1007/s13205-023-03726-5获取的补充材料。
