Jiang Yu-Shi, Li Shan-Shan, Luo Xue-Ling, Chen Li-Ning, Chen Dan-Na, Xia Peng-Ju
School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, Guangxi 541004, People's Republic of China.
Org Lett. 2023 Sep 15;25(36):6671-6676. doi: 10.1021/acs.orglett.3c02533. Epub 2023 Aug 29.
In this study, a metal-free difunctionalization strategy for diazenes was developed using a range of bifunctionalization reagents. This strategy involves a unique N(sp)-N(sp) radical coupling between the hydrazine radical and the imine radical. More than 30 triazane core motifs were constructed by installing imines and various functional groups, including alkyl, phenyl, cyanoalkyl, and sulfonyl groups, on both ends of the nitrogen-nitrogen bond of diazenes in an efficient manner.
在本研究中，利用一系列双官能化试剂开发了一种用于重氮化合物的无金属双官能化策略。该策略涉及肼基自由基与亚胺基自由基之间独特的N(sp)-N(sp)自由基偶联。通过在重氮化合物氮氮键的两端高效地引入亚胺和各种官能团，包括烷基、苯基、氰基烷基和磺酰基，构建了30多种三氮烷核心基序。
