Schäfer Felix, Lückemeier Lukas, Glorius Frank
Universität Münster, Organisch-Chemisches Institut Corrensstraße 36 48149 Münster Germany
Chem Sci. 2024 Aug 30;15(36):14548-55. doi: 10.1039/d4sc03017f.
The fluctuating reproducibility of scientific reports presents a well-recognised issue, frequently stemming from insufficient standardisation, transparency and a lack of information in scientific publications. Consequently, the incorporation of newly developed synthetic methods into practical applications often occurs at a slow rate. In recent years, various efforts have been made to analyse the sensitivity of chemical methodologies and the variation in quantitative outcome observed across different laboratory environments. For today's chemists, determining the key factors that really matter for a reaction's outcome from all the different aspects of chemical methodology can be a challenging task. In response, we provide a detailed examination and customised recommendations surrounding the sensitivity screen, offering a comprehensive assessment of various strategies and exploring their diverse applications by research groups to improve the practicality of their methodologies.
科学报告的可重复性波动是一个公认的问题，这通常源于科学出版物中标准化不足、透明度不够以及信息缺乏。因此，新开发的合成方法在实际应用中的纳入往往进展缓慢。近年来，人们已经做出了各种努力来分析化学方法的灵敏度以及在不同实验室环境中观察到的定量结果的变化。对于当今的化学家来说，从化学方法的所有不同方面确定对反应结果真正重要的关键因素可能是一项具有挑战性的任务。作为回应，我们围绕灵敏度筛选提供了详细的审查和定制建议，对各种策略进行了全面评估，并探讨了研究小组对其的不同应用，以提高其方法的实用性。
