Komiyama A, Saitoh H, Yamazaki M, Kawai H, Miyagawa Y, Akabane T, Ichikawa M, Shigematsu H
Scand J Haematol. 1986 Aug;37(2):162-7. doi: 10.1111/j.1600-0609.1986.tb01791.x.
Phagocytic capacity of circulating neutrophils and monocytes was studied by electron microscopy in 2 children with Chédiak-Higashi syndrome (CHS). Apparent phagocytosis of autologous leucocytes by the CHS neutrophils and monocytes was demonstrated when they were coincubated with Staphylococcus aureus in vitro, indicating their capacity for hyperactive phagocytosis. The hyperactive phagocytic capacity of the CHS phagocytes was a cellular abnormality. CHS neutrophils and monocytes are known to be defective in chemotaxis and bactericidal capacity, and the hyperactive phagocytic capacity is another functional abnormality of CHS phagocytes.
通过电子显微镜研究了2例患有切迪阿克-希加希综合征（CHS）的儿童循环中性粒细胞和单核细胞的吞噬能力。当CHS中性粒细胞和单核细胞与金黄色葡萄球菌在体外共同孵育时，可观察到它们对自体白细胞的明显吞噬作用，表明它们具有活跃的吞噬能力。CHS吞噬细胞活跃的吞噬能力是一种细胞异常。已知CHS中性粒细胞和单核细胞在趋化性和杀菌能力方面存在缺陷，而活跃的吞噬能力是CHS吞噬细胞的另一种功能异常。
