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1
A new phase of the Cancer Moonshot to end cancer as we know it.癌症登月计划的新阶段,旨在终结我们所知的癌症。
Nat Med. 2022 Jul;28(7):1345-1347. doi: 10.1038/s41591-022-01881-5.
2
Why animal model studies are lost in translation.为何动物模型研究在转化过程中出现问题。
J Cardiovasc Aging. 2022 Apr;2(2). doi: 10.20517/jca.2022.10. Epub 2022 Mar 31.
3
Human organs-on-chips for disease modelling, drug development and personalized medicine.用于疾病建模、药物开发和个性化医疗的人体器官芯片。
Nat Rev Genet. 2022 Aug;23(8):467-491. doi: 10.1038/s41576-022-00466-9. Epub 2022 Mar 25.
4
Perspectives on the evaluation and adoption of complex in vitro models in drug development: Workshop with the FDA and the pharmaceutical industry (IQ MPS Affiliate).药物研发中复杂体外模型的评估与应用前景:与美国食品药品监督管理局及制药行业的研讨会(IQ微生理系统联盟)
ALTEX. 2022;39(2):297–314. doi: 10.14573/altex.2112203. Epub 2022 Jan 21.
5
Progress and potential: The Cancer Moonshot.进展与潜力:癌症“登月计划”。
Cancer Cell. 2021 Jul 12;39(7):889-894. doi: 10.1016/j.ccell.2021.04.015. Epub 2021 May 6.
6
Healthy and diseased models of vascular systems.血管系统的健康和疾病模型。
Lab Chip. 2021 Feb 23;21(4):641-659. doi: 10.1039/d0lc00464b.
7
Chemotherapeutic Drug Delivery and Quantitative Analysis of Proliferation, Apoptosis, and Migration in a Tissue-Engineered Three-Dimensional Microvessel Model of the Tumor Microenvironment.肿瘤微环境的组织工程三维微血管模型中的化疗药物递送以及增殖、凋亡和迁移的定量分析
ACS Biomater Sci Eng. 2019 Feb 11;5(2):633-643. doi: 10.1021/acsbiomaterials.8b00877. Epub 2018 Dec 31.
8
Humans: the ultimate animal models.人类:终极动物模型。
J Neurol Neurosurg Psychiatry. 2020 Nov;91(11):1132-1136. doi: 10.1136/jnnp-2020-323016. Epub 2020 Aug 7.
9
A Tissue-Engineered 3D Microvessel Model Reveals the Dynamics of Mosaic Vessel Formation in Breast Cancer.一种组织工程化 3D 微血管模型揭示了乳腺癌中镶嵌血管形成的动力学。
Cancer Res. 2020 Oct 1;80(19):4288-4301. doi: 10.1158/0008-5472.CAN-19-1564. Epub 2020 Jul 14.
10
Recommended Guidelines for Developing, Qualifying, and Implementing Complex In Vitro Models (CIVMs) for Drug Discovery.用于药物发现的复杂体外模型(CIVMs)开发、鉴定及实施的推荐指南。
SLAS Discov. 2020 Dec;25(10):1174-1190. doi: 10.1177/2472555220923332. Epub 2020 Jun 4.

The Cancer Moonshot, the role of in vitro models, model accuracy, and the need for validation.

作者信息

Searson Peter C

机构信息

Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA.

Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.

出版信息

Nat Nanotechnol. 2023 Oct;18(10):1121-1123. doi: 10.1038/s41565-023-01486-0.

DOI:10.1038/s41565-023-01486-0
PMID:37644124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12045577/
Abstract
摘要