Ghasemian Majid, Poodineh Jafar
Department of Clinical Biochemistry, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran.
Cancer Cell Int. 2023 Aug 29;23(1):184. doi: 10.1186/s12935-023-03037-y.
Long non-coding RNA papillary thyroid carcinoma susceptibility candidate 3 (LncRNA PTCSC3) is located on human chromosome 14q13.3. PTCSC3 functions as a tumor suppressor lncRNA to regulate essential cellular processes such as apoptosis, cell proliferation, migration, invasion, angiogenesis, and epithelial-to-mesenchymal transition. PTCSC3 is also involved in the regulation of the Wnt/β-catenin signaling pathway, aerobic glycolysis, and p53 pathways. Downregulation of PTCSC3 has been associated with an increased risk of many tumors such as thyroid, gastric, laryngeal, breast, cervical, oral, lung, and glioma cancers. In addition, dysregulation of PTCSC3 has been reported in non-cancerous disorders notably osteoporosis and periodontitis. However, a number of single nucleotide polymorphisms at PTCSC3 have been linked to a higher risk of human diseases. This literature review summarizes the diagnostic, prognostic, and the clinical value of abnormal expression of PTCSC3 in cancerous and non-cancerous disorders and comprehensively analyzes potential molecular regulatory mechanism related to PTCSC3, which is expected to provide clear guidance for future PTCSC3 research.
长链非编码RNA甲状腺乳头状癌易感候选基因3（LncRNA PTCSC3）位于人类染色体14q13.3。PTCSC3作为一种肿瘤抑制性长链非编码RNA，可调节细胞凋亡、细胞增殖、迁移、侵袭、血管生成以及上皮-间质转化等重要细胞过程。PTCSC3还参与Wnt/β-连环蛋白信号通路、有氧糖酵解和p53通路的调控。PTCSC3的下调与甲状腺癌、胃癌、喉癌、乳腺癌、宫颈癌、口腔癌、肺癌和神经胶质瘤等多种肿瘤的发病风险增加有关。此外，在非癌性疾病尤其是骨质疏松症和牙周炎中也有PTCSC3失调的报道。然而，PTCSC3的一些单核苷酸多态性与人类疾病的较高风险相关。本文献综述总结了PTCSC3异常表达在癌性和非癌性疾病中的诊断、预后及临床价值，并全面分析了与PTCSC3相关的潜在分子调控机制，有望为未来PTCSC3的研究提供明确指导。
