Khalil Sondos K, Saeed Leena, Fadul Abdalla, Elawad Mohamed F, Ferih Khaled
Internal Medicine Department, Hamad Medical Corporation, Doha, QAT.
Radiology, Hamad General Hospital, Doha, QAT.
Cureus. 2023 Jul 28;15(7):e42600. doi: 10.7759/cureus.42600. eCollection 2023 Jul.
Multiple myeloma patients are recognized to have a higher risk of venous thrombosis. The cause of this could be attributed to several risk factors, such as circulating prothrombotic microparticles, disease-specific variables, and alterations in coagulation and fibrinolysis factors. Recent research has revealed that these individuals also experience greater arterial thrombosis, including acute myocardial infarction and stroke. In this case report, we present the clinical profile and management of a 42-year-old patient who presented with signs and symptoms of deep venous thrombosis (DVT) and was diagnosed with multiple myeloma. The aim of this case report is to highlight a rare clinical presentation and diagnostic workup in a patient with multiple myeloma. Additionally, we discuss the possible factors provoking the development of DVT as a first presentation before treatment initiation and their possible mechanisms.
多发性骨髓瘤患者被认为有更高的静脉血栓形成风险。其原因可归因于多种危险因素，如循环促血栓形成微粒、疾病特异性变量以及凝血和纤维蛋白溶解因子的改变。最近的研究表明，这些个体还更容易发生动脉血栓形成，包括急性心肌梗死和中风。在本病例报告中，我们介绍了一名42岁患者的临床情况及治疗过程，该患者出现了深静脉血栓形成（DVT）的体征和症状，并被诊断为多发性骨髓瘤。本病例报告的目的是强调多发性骨髓瘤患者一种罕见的临床表现和诊断检查。此外，我们还讨论了在开始治疗前引发DVT作为首发表现的可能因素及其可能机制。
