Escovar Javier, Patil Sachin M, Roland William
Department of Medicine, Division of Infectious Diseases, Clinical Fellow, University of Missouri Hospital and Clinic, 1 Hospital Dr, Columbia, MO 65212, USA.
Department of Medicine, Division of Pulmonary, Critical Care and Environmental Medicine, University of Missouri Hospital and Clinic, 1 Hospital Dr, Columbia, MO 65212, USA.
IDCases. 2023 Jun 7;33:e01812. doi: 10.1016/j.idcr.2023.e01812. eCollection 2023.
Tularemia is a severe zoonotic disease caused by gram-negative bacillus . species account for most cases in the United States of America (USA). Apart from the six classical clinical presentations that include glandular, ulceroglandular, oculoglandular, pharyngeal, typhoidal, and pneumonic, skeletal disease is uncommon. Rare clinical manifestations include primary and secondary skin rashes, erythema nodosum, and erythema multiforme. Infrequent skeletal manifestations have presented as osteomyelitis and prosthetic joint infections. Prosthetic joint infection by is a rarity. PubMed literature review revealed a total of five prosthetic joint infection cases. Here we report the sixth and the third case in the USA in a 73-year-old white male with an acute left knee prosthetic joint infection (occurring after a recent episode of left lower extremity cellulitis with septic shock) successfully treated with 14 days of doxycycline.
兔热病是一种由革兰氏阴性杆菌引起的严重人畜共患病。在美国，该病菌种导致了大多数病例。除了六种典型的临床表现，包括腺型、溃疡腺型、眼腺型、咽型、伤寒型和肺型外，骨骼疾病并不常见。罕见的临床表现包括原发性和继发性皮疹、结节性红斑和多形红斑。不常见的骨骼表现为骨髓炎和人工关节感染。由该病菌引起的人工关节感染很罕见。PubMed文献综述显示共有5例人工关节感染病例。在此，我们报告美国的第六例也是第三例病例，一名73岁白人男性发生急性左膝人工关节感染（在近期一次左下肢蜂窝织炎伴感染性休克后发生），经14天强力霉素治疗成功治愈。
