Key Laboratory of Industrial Microbiology, Ministry of Education and Tianjin City, College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300450, China.
School of Materials Science and Engineering, Smart Sensing Interdisciplinary Science Center, Nankai University & TKL of Metal and Molecule Based Material Chemistry, Tianjin 300350, China.
Dalton Trans. 2023 Sep 19;52(36):12909-12917. doi: 10.1039/d3dt01975f.
Metal-organic frameworks (MOFs) have shown significant potential for drug delivery applications. However, there remains a scarcity of comprehensive research addressing the influence of surface properties of MOFs on drug release kinetics and drug solubility. This study focuses on examining the influence of MOFs hydrophilicity and hydrophobicity on the controlled release and solubility of drugs. To achieve this, we prepared drug-loaded nanoparticles through synthesis and created a drug-MOF co-amorphous system using the ball milling technique. Under neutral conditions, the hydrophilic MOF-based drug delivery system demonstrated a comparatively slower drug release profile than its hydrophobic counterpart. This observation suggests that the hydrophilic system holds promise in mitigating drug side effects by enabling improved control over drug release. The implementation of hydrophobic MOFs in co-amorphous systems yields a more pronounced effect on enhancing solubility compared to hydrophilic MOFs. This study offers valuable insights for achieving optimal drug release kinetics and solubility by delicately manipulating surface properties of MOFs.
金属-有机骨架（MOFs）在药物传递应用中显示出了巨大的潜力。然而，仍然缺乏全面的研究来解决 MOFs 表面性质对药物释放动力学和药物溶解度的影响。本研究专注于研究 MOFs 的亲水性和疏水性对药物控制释放和溶解度的影响。为了实现这一目标，我们通过合成制备了载药纳米粒子，并使用球磨技术创建了药物-MOF 共无定形系统。在中性条件下，基于亲水 MOF 的药物传递系统显示出比其疏水对应物更慢的药物释放曲线。这一观察结果表明，亲水系统通过改善药物释放控制，有望减轻药物的副作用。在共无定形系统中使用疏水性 MOFs 相比于亲水性 MOFs 更能显著提高溶解度。本研究为通过精细地调控 MOFs 的表面性质来实现最佳的药物释放动力学和溶解度提供了有价值的见解。
