College of Food Science and Technology, Bohai University, Jinzhou 121013, PR China.
College of Food Science and Technology, Bohai University, Jinzhou 121013, PR China; National Research Center of Soybean Engineering and Technology, Northeast Agricultural University, Harbin 150000, PR China.
Carbohydr Polym. 2022 Feb 15;278:118915. doi: 10.1016/j.carbpol.2021.118915. Epub 2021 Nov 22.
The present study focused on the integration of beta-cyclodextrin based metal-organic frameworks (β-CDMOF) with polymer to obtain hybrid materials with advantageous properties compared to traditional single-component polymers or metal-organic frameworks (MOF) matrixes. We fabricated two complexes with different morphology and structure. During the in situ growth of β-CDMOF around the hydrogel, potassium ions on polysaccharides gradually dissociated to participate in the growth of crystals, while other potassium ions on the carboxylic acid groups provided bridges between crystals and hydrogel, forming a necklace-shaped complex (SHPs@β-CDMOF). Hydrogen bonding and coordination interactions between β-CDMOF and hydrogel are present in a dendritic sandwich-shaped complex (β-CDMOF@SHPs). Furthermore, using the hydrophobic molecule curcumin as a model drug, we have demonstrated that SHPs@β-CDMOF and β-CDMOF@SHPs hybrid materials stabilize the included drug and have potential for controlled drug release. Collectively, the integration of MOF with polymer holds a great promise for drug delivery applications.
本研究专注于将β-环糊精基金属-有机骨架（β-CDMOF）与聚合物整合，以获得具有比传统单一成分聚合物或金属-有机骨架（MOF）基质更有利性能的混合材料。我们制备了两种具有不同形态和结构的复合物。在水凝胶周围原位生长β-CDMOF 时，多糖上的钾离子逐渐解离以参与晶体的生长，而羧酸基团上的其他钾离子则在晶体和水凝胶之间提供桥接，形成项链状复合物（SHPs@β-CDMOF）。β-CDMOF 和水凝胶之间存在氢键和配位相互作用，形成树枝状三明治状复合物（β-CDMOF@SHPs）。此外，使用疏水分子姜黄素作为模型药物，我们证明了 SHP@β-CDMOF 和β-CDMOF@SHPs 混合材料可以稳定包含的药物，并具有控制药物释放的潜力。总的来说，MOF 与聚合物的整合为药物输送应用带来了很大的前景。
