Department of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region , Hong Kong, China.
Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region , Hong Kong, China.
mSystems. 2023 Oct 26;8(5):e0052123. doi: 10.1128/msystems.00521-23. Epub 2023 Aug 30.
Eczema is a major allergic disease in children, which is particularly prevalent in Chinese children during their first year of life. In this study, we showed that alterations in the infant gut microbiota precede the development of eczema in a prospective Chinese cohort. In particular, we discovered enrichments of the genera and in the cases at 3 and 1 month of age, respectively, which may represent potential targets for intervention to prevent eczema. Besides, we identified a depletion of from 1 to 6 months of age and an enrichment of at 3 months in the eczema cases, patterns also observed in C-section-born infants within the same time frames, providing first evidence to support a role of the gut microbiota in previously reported associations between C-section and increased risk of eczema in infancy.
特应性皮炎是儿童期的一种主要过敏性疾病，在我国儿童中尤其普遍，首现于生命的第一年。本研究中，我们前瞻性的中国队列研究显示，特应性皮炎患儿的肠道菌群改变早于特应性皮炎的发生。特别的是，我们发现 3 月龄和 1 月龄时的病例中分别有 和 属的富集，这可能代表着预防特应性皮炎的潜在干预靶点。此外，我们还发现，从 1 月龄到 6 月龄时，以及在特应性皮炎病例中 3 月龄时， 的丰度降低，在同一时间范围内，剖宫产出生的婴儿中也观察到了 的富集，这为肠道微生物群在先前报道的剖宫产与婴儿期特应性皮炎风险增加之间的关联中所起的作用提供了初步证据。
