Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil.
Rev Paul Pediatr. 2023 Aug 25;42:e2022164. doi: 10.1590/1984-0462/2024/42/2022164. eCollection 2023.
To analyze the cognitive development of preterm infants at six and 12 months of corrected age and the associations with perinatal and socioeconomic factors.
Cognitive development of 40 infants (20 preterm and 20 full-term) at six and 12 months of age was evaluated using the Bayley-III scale. Correlations between cognitive outcome and associated factors were assessed using Spearman correlation. Stepwise multiple linear regression analysis with covariance was applied to identify changes on cognitive score between six and 12 months.
Bayley-III cognitive score in preterm group was significantly lower than in full-term group at both six and 12 months of age. Birth weight correlated with cognitive performance at six months and head circumference at birth at 12 months, in full-terms infants. The occurrence of necrotizing enterocolitis was inversely associated with cognitive score in preterms at 12 months. An increase in cognitive score was observed between six and 12 months in both groups, but the gain was more pronounced in preterms.
These findings suggest some cognitive recovery capacity in the first year despite the restrictions imposed by premature birth and emphasize the importance of early interventions in this population.
分析早产儿在矫正后 6 个月和 12 个月时的认知发展情况,并探讨其与围产期和社会经济因素的关系。
采用贝利婴幼儿发展量表评估 40 名婴儿(20 名早产儿和 20 名足月儿)在 6 个月和 12 个月时的认知发育情况。采用 Spearman 相关分析评估认知结局与相关因素之间的相关性。采用协方差逐步多元线性回归分析来确定认知评分在 6 个月至 12 个月之间的变化。
在 6 个月和 12 个月时,早产儿组的贝利婴幼儿发展量表认知评分明显低于足月儿组。在足月儿中,出生体重与 6 个月时的认知表现相关,头围与 12 个月时的认知表现相关。坏死性小肠结肠炎的发生与早产儿 12 个月时的认知评分呈负相关。两组的认知评分在 6 个月至 12 个月之间均有所增加,但早产儿的增加更为明显。
这些发现表明,尽管早产儿出生存在限制,但在第一年仍存在一定的认知恢复能力,这强调了在该人群中进行早期干预的重要性。