Harbourne T, Nicolaides A N
Thromb Res. 1986 Sep 15;43(6):657-62. doi: 10.1016/0049-3848(86)90102-7.
Plasma antithrombin III (AT-III) levels were measured in 61 patients undergoing general surgery. The patients were randomly allocated to a test or a control group. The test group received 5000iu of subcutaneous heparin two hours before operation and then twelve hourly for seven days. The control group received subcutaneous saline. Plasma levels of AT-III and of heparin were estimated before operation, at two, four and six hours after heparin injection on the day of operation and thereafter before the morning injection on the first, third and sixth postoperative days. Antithrombin III decreased progressively during and after operation in both groups. The decrease was greater in the test group at six hours after the first injection. These findings support the hypothesis that AT-III is consumed during coagulation and its utilization is increased in the presence of heparin.
对61例接受普通外科手术的患者测定了血浆抗凝血酶III（AT - III）水平。患者被随机分为试验组或对照组。试验组在手术前两小时皮下注射5000国际单位肝素，然后每12小时注射一次，共注射七天。对照组皮下注射生理盐水。在手术前、手术当天肝素注射后两小时、四小时和六小时以及术后第一天、第三天和第六天早晨注射前，分别测定血浆AT - III和肝素水平。两组患者在手术期间及术后AT - III均逐渐下降。首次注射后六小时试验组下降幅度更大。这些发现支持了以下假设：AT - III在凝血过程中被消耗，并且在肝素存在的情况下其利用率会增加。
