恶性疾病放射治疗过程中痛苦评分的研究的最终结果。

Final Results of a Study Evaluating the Course of Distress Scores During Radiotherapy for Malignant Diseases.

机构信息

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.

Medical Practice for Radiotherapy and Radiation Oncology, Hannover, Germany.

出版信息

Anticancer Res. 2023 Sep;43(9):4143-4148. doi: 10.21873/anticanres.16604.

DOI:10.21873/anticanres.16604

PMID:37648300

Abstract

BACKGROUND/AIM: Patients who receive radiotherapy (RT) may experience significant distress. This study investigated distress scores during RT for a variety of malignancies.

PATIENTS AND METHODS

Distress thermometers (scores of 0-10 points) were completed by 927 patients at baseline and end of RT. Six characteristics were evaluated for changes of distress scores including age, sex, Karnofsky performance score (KPS), tumor type, intent of treatment, and previous RT.

RESULTS

Mean distress scores were 4.9 (±2.7) at baseline and 4.6 (±2.7) at the end of RT; mean change was -0.3 (±2.8) points. On univariable analysis, increased distress (≥2 points) was significantly associated with KPS 90-100 (p<0.001) and curative intent (p=0.040). Trends were found for age ≤64 years (p=0.062), head-and-neck cancer (p=0.076), and no prior RT (p=0.055). In patients with baseline scores ≤5 points, deterioration rates were 30-47%.

CONCLUSION

Psychological support should be offered to all patients undergoing RT. This would benefit particularly patients with risk factors for increased distress.

摘要

背景/目的：接受放疗（RT）的患者可能会经历明显的痛苦。本研究调查了多种恶性肿瘤患者在接受 RT 期间的痛苦评分。

患者和方法

927 名患者在基线和 RT 结束时完成了痛苦温度计（0-10 分）。评估了 6 个特征对痛苦评分的变化，包括年龄、性别、卡氏行为状态评分（KPS）、肿瘤类型、治疗意图和之前的 RT。

结果

基线时的平均痛苦评分为 4.9（±2.7），RT 结束时为 4.6（±2.7）；平均变化为-0.3（±2.8）点。单变量分析显示，较高的痛苦（≥2 分）与 KPS 90-100（p<0.001）和治愈性意图（p=0.040）显著相关。年龄≤64 岁（p=0.062）、头颈部癌症（p=0.076）和无先前 RT（p=0.055）存在趋势。在基线评分≤5 分的患者中，恶化率为 30-47%。